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    Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306375, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Csgalnact1provided by RGD
    Official Full Name
    chondroitin sulfate N-acetylgalactosaminyltransferase 1provided by RGD
    Primary source
    RGD:1307618
    See related
    Ensembl:ENSRNOG00000013024 AllianceGenome:RGD:1307618
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Chgn; RGD1307618
    Summary
    Predicted to enable hexosyltransferase activity. Predicted to be involved in chondroitin sulfate proteoglycan biosynthetic process and nucleotide-sugar metabolic process. Predicted to act upstream of or within chondroitin sulfate metabolic process; extracellular matrix organization; and skeletal system development. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Orthologous to human CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 54.0), Thymus (RPKM 53.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Csgalnact1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (25761946..26097306)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (20995210..21330586)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (22704318..23075071)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482365 Neighboring gene integrator complex subunit 10 Neighboring gene ribosomal protein L10, pseudogene 7 Neighboring gene splicing factor YJU2-like Neighboring gene uncharacterized LOC120097455 Neighboring gene SH2 domain containing 4A Neighboring gene uncharacterized LOC134482490

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis. Gotoh M, et al. J Biol Chem, 2002 Oct 11. PMID 12163485
    2. Molecular cloning and expression of a human chondroitin synthase. Kitagawa H, et al. J Biol Chem, 2001 Oct 19. PMID 11514575
    3. Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism. Sato T, et al. J Biol Chem, 2011 Feb 18. PMID 21148564, Free PMC Article
    4. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Watanabe Y, et al. Biochem J, 2010 Nov 15. PMID 20812917, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidoglycan glycosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylgalactosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP-glucuronate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endochondral ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chondroitin sulfate N-acetylgalactosaminyltransferase 1
    Names
    chondroitin beta1,4 N-acetylgalactosaminyltransferase
    NP_001100779.1
    XP_006253089.1
    XP_006253090.1
    XP_006253091.1
    XP_008769336.1
    XP_008769338.1
    XP_017455585.1
    XP_038950422.1
    XP_038950423.1
    XP_063131449.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107309.1 → NP_001100779.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1

      See identical proteins and their annotated locations for NP_001100779.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474045
      UniProtKB/TrEMBL
      B5DEY9, F7FDK7
      Related
      ENSRNOP00000017822.4, ENSRNOT00000017822.6
      Conserved Domains (1) summary
      cl11394
      Location:68 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      25761946..26097306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275379.1 → XP_063131449.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      B5DEY9, F7FDK7

    2. XM_039094494.2 → XP_038950422.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      B5DEY9, F7FDK7
      Conserved Domains (1) summary
      cl11394
      Location:68 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    3. XM_017600096.3 → XP_017455585.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      B5DEY9, F7FDK7
      Conserved Domains (1) summary
      cl11394
      Location:68 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    4. XM_008771114.4 → XP_008769336.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_008769336.1

      UniProtKB/TrEMBL
      B5DEY9, F7FDK7
      Conserved Domains (1) summary
      cl11394
      Location:68 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    5. XM_039094495.2 → XP_038950423.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      B5DEY9, F7FDK7
      Conserved Domains (1) summary
      cl11394
      Location:68 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    6. XM_006253028.5 → XP_006253090.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253090.1

      UniProtKB/TrEMBL
      B5DEY9, F7FDK7
      Conserved Domains (1) summary
      cl11394
      Location:68 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    7. XM_008771116.4 → XP_008769338.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_008769338.1

      UniProtKB/TrEMBL
      B5DEY9, F7FDK7
      Conserved Domains (1) summary
      cl11394
      Location:68 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    8. XM_006253029.5 → XP_006253091.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253091.1

      UniProtKB/TrEMBL
      B5DEY9, F7FDK7
      Conserved Domains (1) summary
      cl11394
      Location:68 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    9. XM_006253027.4 → XP_006253089.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253089.1

      UniProtKB/TrEMBL
      B5DEY9, F7FDK7
      Conserved Domains (1) summary
      cl11394
      Location:68 → 505
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein Strain
    Heading Accession and Version

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