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    Dipk2a divergent protein kinase domain 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315891, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Dipk2aprovided by RGD
    Official Full Name
    divergent protein kinase domain 2Aprovided by RGD
    Primary source
    RGD:1309079
    See related
    Ensembl:ENSRNOG00000008519 AllianceGenome:RGD:1309079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab2-095; RGD1309079
    Summary
    Predicted to be involved in cardiac muscle cell proliferation; positive regulation of protein kinase C activity; and regulation of phosphatidylinositol 3-kinase signaling. Predicted to act upstream of or within negative regulation of smooth muscle cell apoptotic process. Predicted to be located in COPI-coated vesicle; Golgi membrane; and extracellular region. Predicted to be part of COPI vesicle coat. Predicted to be active in extracellular space. Orthologous to human DIPK2A (divergent protein kinase domain 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 334.7), Liver (RPKM 227.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dipk2a in Genome Data Viewer
    Location:
    8q31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (103950345..103969461, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (95070695..95089815, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (102140713..102159828, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 4A, pseudogene 2 Neighboring gene uncharacterized LOC120094230 Neighboring gene uncharacterized LOC134480087 Neighboring gene uncharacterized LOC102552709 Neighboring gene uncharacterized LOC103690449

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. Beigi F, et al. Circ Res, 2013 Aug 2. PMID 23784961, Free PMC Article
    2. HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. Huang J, et al. J Mol Cell Cardiol, 2014 Jan. PMID 24269490, Free PMC Article
    3. Novel Golgi protein, GoPro49, is a specific dental follicle marker. Takatalo MS, et al. J Dent Res, 2009 Jun. PMID 19587158
    4. Expression of the novel Golgi protein GoPro49 is developmentally regulated during mesenchymal differentiation. Takatalo M, et al. Dev Dyn, 2008 Aug. PMID 18651652
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in COPI-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    divergent protein kinase domain 2A
    Names
    deleted in autism protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134472.1 → NP_001127944.1  divergent protein kinase domain 2A

      See identical proteins and their annotated locations for NP_001127944.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K1M5, A6I250
      Related
      ENSRNOP00000071903.1, ENSRNOT00000086491.2
      Conserved Domains (1) summary
      pfam12260
      Location:206 → 405
      PIP49_C; Protein-kinase domain of FAM69

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      103950345..103969461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047890.1: Suppressed sequence

      Description
      NM_001047890.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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