Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cyp2c7provided by RGD
Full Name: cytochrome P450, family 2, subfamily c, polypeptide 7provided by RGD
Primary source: RGD:620379
See related: Ensembl:ENSRNOG00000021405 AllianceGenome:RGD:620379
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp2c39
Summary: Predicted to enable heme binding activity and monooxygenase activity. Involved in several processes, including response to ethanol; response to lipopolysaccharide; and response to retinoic acid. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Orthologous to human CYP2C8 (cytochrome P450 family 2 subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 12472.5) See more
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Genomic context

Location:: 1q53

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (247966295..248022393)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (237332641..237388714)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (147422999..148119979, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP2C7 is an endothelial epoxyeicosatrienoic acid (EET) synthase in the female rat vasculature, by which, in nitric oxide deficiency, shear stress stimulates the release of EETs to initiate vasodilation.
Title: A novel vascular EET synthase: role of CYP2C7.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134367 (e-PCR)
- UniSTS:217649

AU048831 (e-PCR)
- UniSTS:145281

D1Got282 (e-PCR)
- UniSTS:114858

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonic acid epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 2C7

Names: CYPIIC7; P450F; PTF1; cytochrome P450 2C7-like; cytochrome P450, 2c39; cytochrome P450F

NP_058854.1

EC 1.14.14.1

XP_038961177.2

EC 1.14.14.1

XP_063140380.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017158.2 → NP_058854.1 cytochrome P450 2C7 precursor

See identical proteins and their annotated locations for NP_058854.1

Status: PROVISIONAL

Source sequence(s)

M18335

UniProtKB/Swiss-Prot

P05179, Q63706

UniProtKB/TrEMBL

Q4QQW7

Related

ENSRNOP00000045029.5, ENSRNOT00000040325.6

Conserved Domains (1) summary

pfam00067
Location:30 → 487

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

247966295..248022393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284310.1 → XP_063140380.1 cytochrome P450 2C7 isoform X2
XM_039105249.2 → XP_038961177.2 cytochrome P450 2C7 isoform X1

UniProtKB/TrEMBL

Q4QQW7