N6amt1 N-6 adenine-specific DNA methyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: N6amt1provided by RGD
Official Full Name: N-6 adenine-specific DNA methyltransferase 1provided by RGD
Primary source: RGD:1311843
See related: Ensembl:ENSRNOG00000001603 AllianceGenome:RGD:1311843
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hemk2; RGD1311843
Summary: Predicted to enable S-adenosyl-L-methionine binding activity and S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in arsonoacetate metabolic process; macromolecule methylation; and toxin metabolic process. Predicted to act upstream of or within positive regulation of cell growth. Predicted to be located in nucleus. Predicted to be part of eRF1 methyltransferase complex. Orthologous to human N6AMT1 (N-6 adenine-specific DNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 95.7), Heart (RPKM 65.2) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (40071017..40083463)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (26584750..26597790)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (27004335..27016690)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

BF417415 (e-PCR)
- UniSTS:249680

BI281238 (e-PCR)
- UniSTS:249429

RH131197 (e-PCR)
- UniSTS:214480

RH129651 (e-PCR)
- UniSTS:212948

RH144456 (e-PCR)
- UniSTS:233701

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables S-adenosylmethionine-dependent methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arsenite methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K12 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-glutamine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
NOT enables site-specific DNA-methyltransferase (adenine-specific) activity	ISO Inferred from Sequence Orthology more info
enables site-specific DNA-methyltransferase (adenine-specific) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arsonoacetate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in methylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in toxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of eRF1 methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: methyltransferase N6AMT1

Names: HemK methyltransferase family member 2; N-6 adenine-specific DNA methyltransferase 1 (putative)

NP_001178521.1

EC 2.1.1.72

XP_038944153.1

EC 2.1.1.72

XP_038944154.1

EC 2.1.1.72

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191592.1 → NP_001178521.1 methyltransferase N6AMT1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I6AGJ1, D4ACA2

Related

ENSRNOP00000002182.5, ENSRNOT00000002182.8

Conserved Domains (2) summary

COG2890
Location:20 → 190

HemK; Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]

cl17173
Location:21 → 213

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

40071017..40083463

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088225.2 → XP_038944153.1 methyltransferase N6AMT1 isoform X1

Conserved Domains (1) summary

cl17173
Location:10 → 148

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039088226.2 → XP_038944154.1 methyltransferase N6AMT1 isoform X1

Conserved Domains (1) summary

cl17173
Location:10 → 148

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...