Apoc3 apolipoprotein C3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apoc3provided by RGD
Official Full Name: apolipoprotein C3provided by RGD
Primary source: RGD:2136
See related: AllianceGenome:RGD:2136
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ApoC-III; apo-CIII
Summary: Predicted to enable high-density lipoprotein particle receptor binding activity; lipase inhibitor activity; and phospholipid binding activity. Involved in several processes, including lipoprotein transport; negative regulation of oxidative phosphorylation; and positive regulation of triglyceride biosynthetic process. Located in extracellular space. Used to study hyperthyroidism; hypothyroidism; and type 1 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in several diseases, including apolipoprotein C-III deficiency; chronic kidney disease; coronary artery disease; familial hyperlipidemia (multiple); and glucose metabolism disease (multiple). Orthologous to human APOC3 (apolipoprotein C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 13253.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (55428172..55430352, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (46531478..46533658, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (50529318..50531498, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet.
Title: FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet.
Unanticipated Enhancement of Intestinal TG Output by Apoc3 ASO Inhibition.
Title: Unanticipated Enhancement of Intestinal TG Output by Apoc3 ASO Inhibition.
hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats
Title: Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats.
Most of the overexpressed genes were downregulated by N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide with significant decreases in Apoc3, Apob, Acaa2, Acsl1, and Slc247a5 gene expression levels.
Title: N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide decreases triglyceride levels by downregulation of Apoc3 gene expression in acute hyperlipidemic rat model.
Apoc3 expression is regulated by HNF4a and COUP-TFII but not by retinoic acid in rat hepatocytes.
Title: The expression of Apoc3 mRNA is regulated by HNF4α and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells.
ApoCIII forms a abundant ribbonlike loop of amyloidogenic protein in triangles and squares with a width of 50 nm.
Title: Amyloid triangles, squares, and loops of apolipoprotein C-III.
Glucose induces apoCIII transcription, which may represent a mechanism linking hyperglycemia, hypertriglyceridemia, and cardiovascular disease in type 2 diabetes.
Title: Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia.
The hepatic expression and activity of PPARalpha, SREBP-1, and hepatocyte nuclear factor-4alpha (HNF-4alpha) were investigated in sedentary rats, were investigated.
Title: Effect of dietary saturated fatty acids on HNF-4α DNA binding activity and ApoCIII mRNA in sedentary rat liver.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134356 (e-PCR)
- UniSTS:217638

D8Wox4 (e-PCR)
- UniSTS:118088

d8rat85 (e-PCR)
- UniSTS:122474

D8Mit7 (e-PCR), detects polymorphism
- UniSTS:119403

D8Arb7 (e-PCR), detects polymorphism
- UniSTS:228204

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables high-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables lipase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid transporter activity	TAS Traceable Author Statement more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in chylomicron remnant clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	TAS Traceable Author Statement more info	PubMed
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cholesterol import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of high-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Cdc42 protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to triglyceride	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride mobilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
part_of chylomicron	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of intermediate-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of intermediate-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein C-III

Names: apolipoprotein C-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271053.1 → NP_001257982.1 apolipoprotein C-III precursor

See identical proteins and their annotated locations for NP_001257982.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AW917416, JAXUCZ010000008

UniProtKB/Swiss-Prot

P06759

UniProtKB/TrEMBL

A6J472

Conserved Domains (1) summary

pfam05778
Location:24 → 90

Apo-CIII; Apolipoprotein CIII (Apo-CIII)
NM_012501.2 → NP_036633.2 apolipoprotein C-III precursor

See identical proteins and their annotated locations for NP_036633.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AW917416, JAXUCZ010000008

UniProtKB/Swiss-Prot

P06759

UniProtKB/TrEMBL

A6J472

Conserved Domains (1) summary

pfam05778
Location:24 → 90

Apo-CIII; Apolipoprotein CIII (Apo-CIII)