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    Insrr insulin receptor-related receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60663, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Insrrprovided by RGD
    Official Full Name
    insulin receptor-related receptorprovided by RGD
    Primary source
    RGD:67399
    See related
    Ensembl:ENSRNOG00000057702 AllianceGenome:RGD:67399
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sirr
    Summary
    Predicted to enable insulin receptor substrate binding activity and insulin-activated receptor activity. Involved in protein autophosphorylation. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Orthologous to human INSRR (insulin receptor related receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 46.6), Thymus (RPKM 10.0) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Insrr in Genome Data Viewer
    Location:
    2q34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175553244..175572676)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173255335..173274800)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187161817..187181400)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene uncharacterized LOC134485635 Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene SH2 domain containing 2A Neighboring gene proline rich mitotic checkpoint control factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two truncated forms of rat insulin receptor-related receptor. Itoh N, et al. J Biol Chem, 1993 Aug 25. PMID 7688734
    2. Tissue-specific expression of the rat insulin receptor-related receptor gene. Shier P, et al. Mol Endocrinol, 1992 May. PMID 1603082
    3. A new member of the insulin receptor family, insulin receptor-related receptor, is expressed preferentially in the kidney. Kurachi H, et al. Biochem Biophys Res Commun, 1992 Sep 16. PMID 1530648
    4. Insulin receptor-related receptor as an extracellular alkali sensor. Deyev IE, et al. Cell Metab, 2011 Jun 8. PMID 21641549, Free PMC Article
    5. Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an inducible CSF1R/IRR-receptor construct in INS-1E beta-cells. Vogel R, et al. Arch Physiol Biochem, 2010 Jul. PMID 20536329

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the influence of a stimulatable IRR-tyrosine kinase on major IR/IGF1R signaling pathways and on proliferation and apoptosis of INS-1E beta-cells
      Title: Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an inducible CSF1R/IRR-receptor construct in INS-1E beta-cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin receptor substrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to alkaline pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within male sex determination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of insulin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    insulin receptor-related protein
    Names
    IR-related receptor
    IRR
    NP_071548.2
    XP_063138512.1
    XP_063138513.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022212.2 → NP_071548.2  insulin receptor-related protein precursor

      See identical proteins and their annotated locations for NP_071548.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/Swiss-Prot
      Q63146, Q64716
      UniProtKB/TrEMBL
      A6J619
      Related
      ENSRNOP00000073224.1, ENSRNOT00000080693.3
      Conserved Domains (6) summary
      cd05032
      Location:972 → 1248
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:819 → 908
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:228 → 275
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:173 → 326
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:346 → 460
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:979 → 1246
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175553244..175572676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282442.1 → XP_063138512.1  insulin receptor-related protein isoform X1

    2. XM_063282443.1 → XP_063138513.1  insulin receptor-related protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64716.3 GenPept UniProtKB/Swiss-Prot:Q64716

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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