S100g S100 calcium binding protein G [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S100gprovided by RGD
Official Full Name: S100 calcium binding protein Gprovided by RGD
Primary source: RGD:2253
See related: Ensembl:ENSRNOG00000004222 AllianceGenome:RGD:2253
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cabp; Cbpi; Calb3; Rncalbd9
Summary: Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in cytoplasm and extracellular space. Orthologous to human S100G (S100 calcium binding protein G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 405.0), Uterus (RPKM 281.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (35337636..35340205)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (31705853..31708422)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (33442820..33445714)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Estrogen-induced CaBP-9k directly combines with ERalpha, suggesting that CaBP-9k is involved in the biological effects mediated by an ER pathway in the GH3 rat pituitary prolactinoma cell line
Title: Differential effects of estrogen and estrogen receptor antagonist, ICI 182 780, on the expression of calbindin-D9k in rat pituitary prolactinoma GH₃ cells.
S100 g is a functional component of E2 genomic effect that accelerates egg transport.
Title: Participation of the oviductal s100 calcium binding protein G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats.
Results suggest that pituitary calbindin-D9k is induced by estrogen in male rats and its expression is predominantly regulated by estrogen receptor alpha, but not ERbeta.
Title: Estrogen regulates the localization and expression of calbindin-D9k in the pituitary gland of immature male rats via the ERalpha-pathway.
There was an increase in the level of CaBP-9k in the uterus, placenta, and extra-embryonic membrane at late gestation, as blood calcium level increased.
Title: Effects of calcitonin and parathyroid hormone on the regulation of cabindin-D(9k) in the uterus, placenta, and fetal membrane of rats related to blood calcium level during late gestation.
Pituitary CaBP-9k expression is regulated during estrous cycle.Expression is mainly controlled by E2 & antagonized by P4. Pituitary CaBP-9k in female rats may be involved in the central function of the reproduction system.
Title: A calcium binding protein, calbindin-D9k, is mainly regulated by estrogen in the pituitary gland of rats during estrous cycle.
The purpose of these studies was to determine the effect of age and diet on the expression of calbindin at the protein and mRNA levels.
Title: Effect of age and dietary calcium on intestinal calbindin D-9k expression in the rat.
Uterine CaBP-9k is induced by 17betaestradiol and endocrine disrupting chemicals via the ERalpha pathway immature rats.
Title: Estrogen receptor alpha pathway is involved in the regulation of Calbindin-D9k in the uterus of immature rats.

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General gene information

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Markers

DXWox38 (e-PCR)
- UniSTS:518743

DXMGH12 (e-PCR)
- UniSTS:122571

DXWox15 (e-PCR)
- UniSTS:119284

DXWox7 (e-PCR)
- UniSTS:119287

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info
enables vitamin D binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein S100-G

Names: 9 kDa CaBP; calbindin 3, (vitamin D-dependent calcium binding protein); calbindin-D9K; calcium-binding protein, intestinal, vitamin D-dependent (9-kDa CaBP); cholecalcin; vitamin D-dependent calcium-binding protein, intestinal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012521.2 → NP_036653.1 protein S100-G

See identical proteins and their annotated locations for NP_036653.1

Status: PROVISIONAL

Source sequence(s)

J02954

UniProtKB/Swiss-Prot

P02634, P51964

UniProtKB/TrEMBL

A6K2N0

Conserved Domains (1) summary

cd00213
Location:12 → 79

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

35337636..35340205

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256888.4 → XP_006256950.1 protein S100-G isoform X1

See identical proteins and their annotated locations for XP_006256950.1

UniProtKB/TrEMBL

A0A8L2Q2C9

Related

ENSRNOP00000005622.4, ENSRNOT00000005622.6

Conserved Domains (1) summary

cd00213
Location:12 → 80

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...