U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cbln2 cerebellin 2 precursor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291388, updated on 25-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cbln2provided by RGD
    Official Full Name
    cerebellin 2 precursorprovided by RGD
    Primary source
    RGD:1309715
    See related
    Ensembl:ENSRNOG00000013654 AllianceGenome:RGD:1309715
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in maintenance of synapse structure; regulation of presynapse assembly; and spontaneous synaptic transmission. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be active in extracellular space and glutamatergic synapse. Orthologous to human CBLN2 (cerebellin 2 precursor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 71.5), Spleen (RPKM 15.9) and 1 other tissue See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cbln2 in Genome Data Viewer
    Location:
    18q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (82215210..82222648)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (79940412..79948766)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (83775568..83783841)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098158 Neighboring gene U1 spliceosomal RNA Neighboring gene ribosome production factor 1, pseudogene 2 Neighboring gene DNA methyltransferase 1-associated protein 1, pseudogene 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning of rat cerebellin-like protein cDNA which encodes a novel membrane-associated glycoprotein. Wada C, et al. Brain Res Mol Brain Res, 1991 Jan. PMID 1850079
    2. Cerebellin in the rat adrenal gland: gene expression and effects of CER and [des-Ser1]CER on the secretion and growth of cultured adrenocortical cells. Rucinski M, et al. Int J Mol Med, 2005 Mar. PMID 15702230
    3. Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs. Seigneur E, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30287486, Free PMC Article
    4. Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin. Tao W, et al. Proc Natl Acad Sci U S A, 2018 Jun 5. PMID 29784783, Free PMC Article
    5. Genetic Ablation of All Cerebellins Reveals Synapse Organizer Functions in Multiple Regions Throughout the Brain. Seigneur E, et al. J Neurosci, 2018 May 16. PMID 29691328, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-kappaB/HIF-1alpha/Twist1 pathway.
      Title: Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-κB/HIF-1α/Twist1 pathway.
    2. Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.
      Title: Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in maintenance of synapse structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of synapse structure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of synapse structure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spontaneous synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spontaneous synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in trans-synaptic signaling, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cerebellin-2
    Names
    cerebellin 2 precursor protein
    cerebellin-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012740.1 → NP_001012758.1  cerebellin-2 precursor

      See identical proteins and their annotated locations for NP_001012758.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091341
      UniProtKB/Swiss-Prot
      P98087, Q5BJT3
      UniProtKB/TrEMBL
      A6K5N0
      Related
      ENSRNOP00000018682.3, ENSRNOT00000018682.5
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      82215210..82222648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096623.2 → XP_038952551.1  cerebellin-2 isoform X1

      UniProtKB/Swiss-Prot
      P98087, Q5BJT3
      UniProtKB/TrEMBL
      A6K5N0
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    2. XM_006255023.5 → XP_006255085.1  cerebellin-2 isoform X1

      See identical proteins and their annotated locations for XP_006255085.1

      UniProtKB/Swiss-Prot
      P98087, Q5BJT3
      UniProtKB/TrEMBL
      A6K5N0
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    3. XM_039096624.2 → XP_038952552.1  cerebellin-2 isoform X1

      UniProtKB/Swiss-Prot
      P98087, Q5BJT3
      UniProtKB/TrEMBL
      A6K5N0
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    RNA

    1. XR_005495996.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98087.1 GenPept UniProtKB/Swiss-Prot:P98087

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous