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    Grk1 G protein-coupled receptor kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81760, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Grk1provided by RGD
    Official Full Name
    G protein-coupled receptor kinase 1provided by RGD
    Primary source
    RGD:619712
    See related
    Ensembl:ENSRNOG00000018430 AllianceGenome:RGD:619712
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rhok
    Summary
    Enables rhodopsin kinase activity. Involved in protein autophosphorylation; response to light stimulus; and response to xenobiotic stimulus. Predicted to be located in photoreceptor outer segment. Predicted to be active in cytoplasm. Used to study congestive heart failure. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 4.0), Brain (RPKM 2.6) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Grk1 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (82821184..82837971, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76122501..76135792, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81153489..81165442)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene growth arrest specific 6 Neighboring gene transmembrane protein 255B Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene transcription factor Dp-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Gurevich EV, et al. Pharmacol Ther, 2012 Jan. PMID 21903131, Free PMC Article
    2. Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction. Phrommintikul A, et al. Am J Physiol Heart Circ Physiol, 2008 Apr. PMID 18245565
    3. Impaired coronary function in Wistar Ottawa Karlsburg W rats-a new model of the metabolic syndrome. Grisk O, et al. Pflugers Arch, 2007 Sep. PMID 17473932
    4. Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure. Leineweber K, et al. Circ Res, 2002 Nov 29. PMID 12456492
    5. Preservation of retinal morphology and functions in royal college surgeons rat by nilvadipine, a Ca(2+) antagonist. Yamazaki H, et al. Invest Ophthalmol Vis Sci, 2002 Apr. PMID 11923229

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.
      Title: AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.
    2. Cytoskeletal reorganization evoked by Rho-associated kinase- and protein kinase C-catalyzed phosphorylation of cofilin and heat shock protein 27, respectively, contributes to myogenic constriction of rat cerebral arteries.
      Title: Cytoskeletal reorganization evoked by Rho-associated kinase- and protein kinase C-catalyzed phosphorylation of cofilin and heat shock protein 27, respectively, contributes to myogenic constriction of rat cerebral arteries.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rhodopsin kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rhodopsin kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rhodopsin kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rhodopsin kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rhodopsin kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within photoreceptor cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic retina morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of opsin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of opsin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of opsin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of retinal rod cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rhodopsin mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rhodopsin kinase GRK1
    Names
    G protein-coupled receptpr kinase 1
    RK
    NP_112358.1
    XP_038950785.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031096.1 → NP_112358.1  rhodopsin kinase GRK1

      See identical proteins and their annotated locations for NP_112358.1

      Status: PROVISIONAL

      Source sequence(s)
      U63971
      UniProtKB/Swiss-Prot
      Q63651
      Related
      ENSRNOP00000024999.2, ENSRNOT00000024999.5
      Conserved Domains (2) summary
      cd05608
      Location:188 → 475
      STKc_GRK1; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1
      cl02565
      Location:42 → 179
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      82821184..82837971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094857.2 → XP_038950785.1  rhodopsin kinase GRK1 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 209
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63651.1 GenPept UniProtKB/Swiss-Prot:Q63651

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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