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    Tpst2 tyrosylprotein sulfotransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288719, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Tpst2provided by RGD
    Official Full Name
    tyrosylprotein sulfotransferase 2provided by RGD
    Primary source
    RGD:1305331
    See related
    Ensembl:ENSRNOG00000000664 AllianceGenome:RGD:1305331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TPST-2
    Summary
    Predicted to enable protein homodimerization activity and protein-tyrosine sulfotransferase activity. Predicted to be involved in peptidyl-tyrosine sulfation. Predicted to act upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization and prevention of polyspermy. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi apparatus. Orthologous to human TPST2 (tyrosylprotein sulfotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 124.0), Heart (RPKM 111.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpst2 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (49982281..50024489, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (44321875..44363892, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (50343076..50383534, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain-containing protein 121-like Neighboring gene HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 Neighboring gene SRR1 domain containing Neighboring gene tuftelin interacting protein 11 Neighboring gene crystallin, beta B1 Neighboring gene crystallin, beta A4 Neighboring gene uncharacterized LOC134481212 Neighboring gene myocardial infarction associated transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction. Teramoto T, et al. Nat Commun, 2013. PMID 23481380, Free PMC Article
    2. Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody. Hoffhines AJ, et al. J Biol Chem, 2006 Dec 8. PMID 17046811, Free PMC Article
    3. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. Marcello MR, et al. J Biol Chem, 2011 Apr 15. PMID 21339297, Free PMC Article
    4. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. Ouyang YB, et al. J Biol Chem, 1998 Sep 18. PMID 9733778
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105657

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-tyrosine sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-tyrosine sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within prevention of polyspermy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-tyrosine sulfotransferase 2
    NP_001008508.2
    XP_038945198.1
    XP_038945200.1
    XP_063127287.1
    XP_063127288.1
    XP_063127289.1
    XP_063127290.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008508.3 → NP_001008508.2  protein-tyrosine sulfotransferase 2

      See identical proteins and their annotated locations for NP_001008508.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q5RJS8
      UniProtKB/TrEMBL
      A0A8L2PYI1, A6J265
      Related
      ENSRNOP00000000831.5, ENSRNOT00000000831.5
      Conserved Domains (1) summary
      pfam13469
      Location:84 → 275
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      49982281..50024489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089270.2 → XP_038945198.1  protein-tyrosine sulfotransferase 2 isoform X4

      UniProtKB/Swiss-Prot
      Q5RJS8
      Conserved Domains (1) summary
      pfam13469
      Location:120 → 311
      Sulfotransfer_3; Sulfotransferase family

    2. XM_063271219.1 → XP_063127289.1  protein-tyrosine sulfotransferase 2 isoform X3

      UniProtKB/Swiss-Prot
      Q5RJS8
      UniProtKB/TrEMBL
      A0A8L2PYI1, A6J265

    3. XM_039089272.2 → XP_038945200.1  protein-tyrosine sulfotransferase 2 isoform X3

      UniProtKB/Swiss-Prot
      Q5RJS8
      UniProtKB/TrEMBL
      A0A8L2PYI1, A6J265
      Conserved Domains (1) summary
      pfam13469
      Location:84 → 275
      Sulfotransfer_3; Sulfotransferase family

    4. XM_063271218.1 → XP_063127288.1  protein-tyrosine sulfotransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ08

    5. XM_063271217.1 → XP_063127287.1  protein-tyrosine sulfotransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ08

    6. XM_063271220.1 → XP_063127290.1  protein-tyrosine sulfotransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ08

    RNA

    1. XR_010056380.1 RNA Sequence

    2. XR_005491621.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJS8.1 GenPept UniProtKB/Swiss-Prot:Q5RJS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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