Hsh2d hematopoietic SH2 domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsh2dprovided by MGI
Official Full Name: hematopoietic SH2 domain containingprovided by MGI
Primary source: MGI:MGI:2676364
See related: Ensembl:ENSMUSG00000062007 AllianceGenome:MGI:2676364
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ALX; Hsh2
Summary: Enables protein-macromolecule adaptor activity. Acts upstream of or within T cell activation; negative regulation of B cell apoptotic process; and negative regulation of mitochondrial depolarization. Located in cytosol and mitochondrion. Is expressed in spleen and thymus. Orthologous to human HSH2D (hematopoietic SH2 domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 12.1), thymus adult (RPKM 5.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.87 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (72943512..72954802)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (72189668..72200958)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data demonstrate that changes in HSH2 expression have profound effects on the humoral immune response.
Title: Differential expression of the adaptor protein HSH2 controls the quantitative and qualitative nature of the humoral response.
Although adaptor in lymphocytes of unknown function X (ALX) is coexpressed with related adaptor Rlk/Itk-binding protein (RIBP) on both T- and B-lymphocytes throughout cell development, no redundancy or synergy is found.
Title: The related adaptors, adaptor in lymphocytes of unknown function X and Rlk/Itk-binding protein, have nonredundant functions in lymphocytes.
HSH2 expression is coordinately up-regulated with known antiapoptotic molecules and directly correlates with B cell survival
Title: Expression of the adaptor protein hematopoietic Src homology 2 is up-regulated in response to stimuli that promote survival and differentiation of B cells.
ALX is an adaptor involved in T cell activation and interleukin-2 (IL-2) promoter activation
Title: Cloning and characterization of ALX, an adaptor downstream of CD28.
endogenous HSH2 expression correlates directly with survival of WEHI-231 cells, which supports the hypothesis that HSH2 modulates the apoptotic response through its ability to directly or indirectly promote mitochondrial stability
Title: The adaptor protein HSH2 attenuates apoptosis in response to ligation of the B cell antigen receptor complex on the B lymphoma cell line, WEHI-231.
These results suggest that ALX, in association with LAX, negatively regulates T-cell activation through inhibition of p38.
Title: Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

D8Mit359 (e-PCR), detects polymorphism
- UniSTS:131575

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mitochondrial depolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hematopoietic SH2 domain-containing protein

Names: adaptor in lymphocytes of unknown function X; adaptor protein ALx2; hematopoietic SH2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_197944.1 → NP_922935.1 hematopoietic SH2 domain-containing protein

See identical proteins and their annotated locations for NP_922935.1

Status: PROVISIONAL

Source sequence(s)

AY319653

Consensus CDS

CCDS22410.1

UniProtKB/Swiss-Prot

Q52KL3, Q6VYH9

Related

ENSMUSP00000071970.7, ENSMUST00000072097.14

Conserved Domains (1) summary

cd09946
Location:26 → 127

SH2_HSH2_like; Src homology 2 domain found in hematopoietic SH2 (HSH2) protein