Nlk nemo like kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nlkprovided by RGD
Official Full Name: nemo like kinaseprovided by RGD
Primary source: RGD:1561602
See related: Ensembl:ENSRNOG00000008704 AllianceGenome:RGD:1561602
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561602
Summary: Predicted to enable several functions, including ATP binding activity; SH2 domain binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including protein phosphorylation; protein stabilization; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within protein autophosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 166.6), Brain (RPKM 158.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63965432..64089006, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63467388..63590960, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65840052..65963932, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-208a can promote Ang II-induced cardiomyocyte apoptosis via negatively regulating NLK expression, and inhibition of miR-208a may provide a novel therapeutic target for cardiomyocyte apoptosis
Title: MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase (NLK).
The results showed that NLK was a direct target of mir-208.
Title: Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 in Hypoxia/Ischemia Injuried Cardiomyocytes.
NLK is decreasingly expressed in an opposite time-course to the development of cerebral vasospasm (CVS) and SAH-induced brain injury
Title: Expression of Nemo-like kinase (NLK) in the brain in a rat experimental subarachnoid hemorrhage model.
A significant down-regulation is found with nemo-like kinase and a concomitant up-regulation of caspase-3 during the early stage of traumatic brain injury.
Title: Nemo-like kinase (NLK) involves in neuronal apoptosis after traumatic brain injury.
Nlk2 gene and Nlkp pseudogene were predicted as retrotransposed Nlk homologs within the rat genome. Nlk2 gene encoded a 480-aa Nlk2 protein with partial deletion within the kinase domain, which was predicted as the dominant negative Nlk homolog.
Title: Comparative genomics on nemo-like kinase gene.

Submit: New GeneRIF Correction

General gene information

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Markers

NLK_1472 (e-PCR)
- UniSTS:277533

BF386532 (e-PCR)
- UniSTS:243770

Nlk-ps1 (e-PCR), detects polymorphism
- UniSTS:239188

D11Bhm63 (e-PCR), detects polymorphism
- UniSTS:141668

D2Abb1e (e-PCR), detects polymorphism
- UniSTS:142287

RH139330 (e-PCR)
- UniSTS:221416

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase NLK

NP_001178853.1

EC 2.7.11.24

XP_038942542.1

EC 2.7.11.24

XP_063125709.1

EC 2.7.11.24

XP_063125710.1

EC 2.7.11.24

XP_063125711.1

EC 2.7.11.24

XP_063125712.1

EC 2.7.11.24

XP_063125713.1

EC 2.7.11.24

XP_063125714.1

EC 2.7.11.24

XP_063125715.1

EC 2.7.11.24

XP_063125716.1

EC 2.7.11.24

XP_063125718.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191924.3 → NP_001178853.1 serine/threonine-protein kinase NLK

See identical proteins and their annotated locations for NP_001178853.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

D3ZSZ3

UniProtKB/TrEMBL

A0A8I6AN12

Related

ENSRNOP00000011726.5, ENSRNOT00000011726.7

Conserved Domains (1) summary

cd07853
Location:137 → 508

STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

63965432..64089006 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086614.2 → XP_038942542.1 serine/threonine-protein kinase NLK isoform X1

UniProtKB/Swiss-Prot

D3ZSZ3

UniProtKB/TrEMBL

A0A8I6AN12

Conserved Domains (1) summary

cd07853
Location:137 → 508

STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
XM_063269645.1 → XP_063125715.1 serine/threonine-protein kinase NLK isoform X3
XM_063269644.1 → XP_063125714.1 serine/threonine-protein kinase NLK isoform X3
XM_063269646.1 → XP_063125716.1 serine/threonine-protein kinase NLK isoform X4
XM_063269643.1 → XP_063125713.1 serine/threonine-protein kinase NLK isoform X3
XM_063269641.1 → XP_063125711.1 serine/threonine-protein kinase NLK isoform X3
XM_063269640.1 → XP_063125710.1 serine/threonine-protein kinase NLK isoform X3
XM_063269642.1 → XP_063125712.1 serine/threonine-protein kinase NLK isoform X3
XM_063269639.1 → XP_063125709.1 serine/threonine-protein kinase NLK isoform X2

UniProtKB/TrEMBL

A6HH68
XM_063269648.1 → XP_063125718.1 serine/threonine-protein kinase NLK isoform X5