Itga2b integrin subunit alpha 2b [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itga2bprovided by RGD
Official Full Name: integrin subunit alpha 2bprovided by RGD
Primary source: RGD:1596428
See related: Ensembl:ENSRNOG00000022071 AllianceGenome:RGD:1596428
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables fibrinogen binding activity. Involved in platelet aggregation and positive regulation of leukocyte migration. Located in cell surface. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 105.0), Liver (RPKM 37.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (87908697..87926225, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87408532..87426055, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (90397960..90416550, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNF-alpha decreases calcium internal mobilization and calcium influx in platelets. TNF-alpha significantly reduced (Tyr 416)-c-Src and (Tyr773)-beta3 subunit of integrin alphaIIbbeta3 phosphorylation.
Title: Platelet activity is negatively modulated by tumor necrosis factor alpha through reductions of cytosolic calcium levels and integrin alphaIIbbeta3 phosphorylation.
Taken together, our results reveal that ND-1 is a novel antagonist of alphaIIb3 with strong antithrombotic effect and lower bleeding risk.
Title: A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3.
PI3K/Akt signaling is utilized by alphaIIb-mediated outside-in signaling to activate platelets.
Title: Integrin αIIb-mediated PI3K/Akt activation in platelets.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139967 (e-PCR)
- UniSTS:222049

Itga2b (e-PCR), detects polymorphism
- UniSTS:256442

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables fibrinogen binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
part_of integrin alphaIIb-beta3 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-IIb

Names: integrin alpha 2b (Cd41b); integrin, alpha 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.