Slc4a1 solute carrier family 4 member 1 (Diego blood group) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc4a1provided by RGD
Official Full Name: solute carrier family 4 member 1 (Diego blood group)provided by RGD
Primary source: RGD:3710
See related: Ensembl:ENSRNOG00000020951 AllianceGenome:RGD:3710
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables actin binding activity; enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including positive regulation of T cell proliferation; response to alkaline pH; and response to carbon dioxide. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of iron deficiency anemia; metabolic acidosis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1804.0) and Kidney (RPKM 205.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (87807010..87823274, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87306865..87323132, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (90296144..90312401, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in the structure and function of erythrocyte band 3.
Title: Cluster of erythrocyte band 3: a potential molecular target of exhaustive exercise-induced dysfunction of erythrocyte deformability.

Submit: New GeneRIF Correction

General gene information

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Markers

D10Wox20 (e-PCR)
- UniSTS:118031

D10Arb13 (e-PCR), detects polymorphism
- UniSTS:226260

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ankyrin binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bicarbonate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables bicarbonate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride:bicarbonate antiporter activity	IEA Inferred from Electronic Annotation more info
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables chloride:bicarbonate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables hemoglobin binding	IEA Inferred from Electronic Annotation more info
enables hemoglobin binding	ISO Inferred from Sequence Orthology more info
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables solute:inorganic anion antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in bicarbonate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in bicarbonate transport	TAS Traceable Author Statement more info	PubMed
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transport	TAS Traceable Author Statement more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in erythrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
involved_in inorganic anion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glycolytic process through fructose-6-phosphate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of glycolytic process through fructose-6-phosphate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in pH elevation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pH elevation	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within plasma membrane phospholipid scrambling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to acidic pH	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to alkaline pH	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in response to carbon dioxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
part_of ankyrin-1 complex	IEA Inferred from Electronic Annotation more info
part_of ankyrin-1 complex	ISO Inferred from Sequence Orthology more info
part_of ankyrin-1 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cortical cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: band 3 anion transport protein

Names: AE 1; Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3); anion exchange protein 1; anion exchanger 1; solute carrier family 4 (anion exchanger), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012651.3 → NP_036783.2 band 3 anion transport protein

See identical proteins and their annotated locations for NP_036783.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K8D8

Related

ENSRNOP00000028445.6, ENSRNOT00000028445.7

Conserved Domains (3) summary

TIGR00834
Location:72 → 927

ae; anion exchange protein

pfam00955
Location:390 → 856

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:100 → 342

Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

87807010..87823274 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008767946.4 → XP_008766168.1 band 3 anion transport protein isoform X2

See identical proteins and their annotated locations for XP_008766168.1

UniProtKB/Swiss-Prot

P23562

UniProtKB/TrEMBL

A0A0G2K8D8

Conserved Domains (3) summary

TIGR00834
Location:72 → 926

ae; anion exchange protein

pfam00955
Location:389 → 855

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:100 → 342

Band_3_cyto; Band 3 cytoplasmic domain
XM_063268427.1 → XP_063124497.1 band 3 anion transport protein isoform X1