Tomm20 translocase of outer mitochondrial membrane 20 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tomm20provided by RGD
Official Full Name: translocase of outer mitochondrial membrane 20provided by RGD
Primary source: RGD:708467
See related: Ensembl:ENSRNOG00000019980 AllianceGenome:RGD:708467
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables mitochondrion targeting sequence binding activity. Involved in protein targeting to mitochondrion; response to 3,3',5-triiodo-L-thyronine; and response to muscle activity. Located in mitochondrial outer membrane. Biomarker of muscular atrophy. Orthologous to human TOMM20 (translocase of outer mitochondrial membrane 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 924.1), Brain (RPKM 800.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (71822429..71832420, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (54925197..54935188, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (59863421..59873411, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease
Title: α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.
The here presented replica-exchange molecular dynamics simulations provide insights into the energetics of the multiple-binding forms of TOM20.
Title: Energetics of the presequence-binding poses in mitochondrial protein import through Tom20.
The distributions of clusters of Tom20 and of Tom22 follow an inner-cellular gradient from the perinuclear to the peripheral mitochondria.
Title: Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient.
confirmed and extended the dynamic, multiple bound state model of the Tom20-presequence interactions and also demonstrated the validity of the molecular tethering and stiffening techniques in studies of transient protein-peptide interactions
Title: Crystallographic snapshots of Tom20-mitochondrial presequence interactions with disulfide-stabilized peptides.
Data show that under conditions of increased ionic strength, the citrate carrier precursor protein presequence binds to Tom20 and accumulates at the mitochondrial surface [Tom20].
Title: Import of rat mitochondrial citrate carrier (CIC) at increasing salt concentrations promotes presequence binding to import receptor Tom20 and inhibits membrane translocation.
Study concludes that the dynamic, multiple-mode interaction is the molecular mechanism facilitating the broadly selective specificity of the Tomm20 receptor toward diverse mitochondrial presequences.
Title: Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134841 (e-PCR)
- UniSTS:218119

RH140946 (e-PCR)
- UniSTS:222948

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mitochondrion targeting sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrion targeting sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables mitochondrion targeting sequence binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-transporting ATPase activity	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to 3,3',5-triiodo-L-thyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in tRNA import into mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in migrasome	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
located_in mitochondrial envelope	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial outer membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial outer membrane translocase complex	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitochondrial import receptor subunit TOM20 homolog

Names: mitochondrial 20 kDa outer membrane protein; outer mitochondrial membrane receptor Tom20; outer mitochondrial membrane receptor rTOM20; translocase of outer mitochondrial membrane 20 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152935.2 → NP_690918.2 mitochondrial import receptor subunit TOM20 homolog

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

O08517, Q62760, Q63804, Q6AZ66

UniProtKB/TrEMBL

A6KJ54

Related

ENSRNOP00000027088.2, ENSRNOT00000027088.3

Conserved Domains (1) summary

TIGR00985
Location:1 → 127

3a0801s04tom; mitochondrial import receptor subunit translocase of outer membrane 20 kDa subunit