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    Armc6 armadillo repeat containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 76813, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Armc6provided by MGI
    Official Full Name
    armadillo repeat containing 6provided by MGI
    Primary source
    MGI:MGI:1924063
    See related
    Ensembl:ENSMUSG00000002343 AllianceGenome:MGI:1924063
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410153K17Rik
    Summary
    Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol. Orthologous to human ARMC6 (armadillo repeat containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 25.6), whole brain E14.5 (RPKM 18.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Armc6 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70672822..70687099, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70220172..70234446, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10504 Neighboring gene transmembrane protein 161A Neighboring gene solute carrier family 25, member 42 Neighboring gene STARR-positive B cell enhancer ABC_E1103 Neighboring gene STARR-positive B cell enhancer ABC_E8239 Neighboring gene SURP and G patch domain containing 2 Neighboring gene predicted gene, 38427 Neighboring gene homer scaffolding protein 3 Neighboring gene DEAD box helicase 49

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. Sampson ND, et al. Gene, 2003 Feb 13. PMID 12594045
    2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC67564

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in hematopoietic progenitor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133972.2 → NP_598733.2  armadillo repeat-containing protein 6

      See identical proteins and their annotated locations for NP_598733.2

      Status: PROVISIONAL

      Source sequence(s)
      BC043070
      Consensus CDS
      CCDS40371.1
      UniProtKB/Swiss-Prot
      Q8BNU0, Q8C4P5, Q8C7S1, Q8K2S7, Q99JQ2, Q9CWE4
      Related
      ENSMUSP00000019679.6, ENSMUST00000019679.12
      Conserved Domains (2) summary
      smart00185
      Location:184 → 226
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:146 → 180
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70672822..70687099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242332.4 → XP_011240634.1  armadillo repeat-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011240634.1

      Conserved Domains (2) summary
      smart00185
      Location:184 → 226
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:146 → 180
      ARM; armadillo repeat [structural motif]

    2. XM_030243842.1 → XP_030099702.1  armadillo repeat-containing protein 6 isoform X2

      UniProtKB/Swiss-Prot
      Q8BNU0, Q8C4P5, Q8C7S1, Q8K2S7, Q99JQ2, Q9CWE4
      Conserved Domains (2) summary
      smart00185
      Location:184 → 226
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:146 → 180
      ARM; armadillo repeat [structural motif]

    3. XM_030243841.2 → XP_030099701.1  armadillo repeat-containing protein 6 isoform X2

      UniProtKB/Swiss-Prot
      Q8BNU0, Q8C4P5, Q8C7S1, Q8K2S7, Q99JQ2, Q9CWE4
      Conserved Domains (2) summary
      smart00185
      Location:184 → 226
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:146 → 180
      ARM; armadillo repeat [structural motif]

    4. XM_011242333.4 → XP_011240635.1  armadillo repeat-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011240635.1

      Conserved Domains (2) summary
      smart00185
      Location:184 → 226
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:146 → 180
      ARM; armadillo repeat [structural motif]

    5. XM_011242334.3 → XP_011240636.1  armadillo repeat-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011240636.1

      Conserved Domains (2) summary
      smart00185
      Location:184 → 226
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:146 → 180
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BNU0.1 GenPept UniProtKB/Swiss-Prot:Q8BNU0

    Gene LinkOut

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