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    Zp3r zona pellucida 3 receptor [ Mus musculus (house mouse) ]

    Gene ID: 22789, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Zp3rprovided by MGI
    Official Full Name
    zona pellucida 3 receptorprovided by MGI
    Primary source
    MGI:MGI:104965
    See related
    Ensembl:ENSMUSG00000042554 AllianceGenome:MGI:104965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SP56
    Summary
    Acts upstream of or within binding activity of sperm to zona pellucida. Located in acrosomal vesicle; cell body; and plasma membrane. Part of zona pellucida receptor complex. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 24.4) See more
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    Genomic context

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    See Zp3r in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130474847..130557371, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130547110..130629634, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CD55 molecule, decay accelerating factor for complement B Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene CD55 molecule, decay accelerating factor for complement Neighboring gene STARR-positive B cell enhancer ABC_E9183 Neighboring gene STARR-positive B cell enhancer ABC_E7745 Neighboring gene STARR-seq mESC enhancer starr_02195 Neighboring gene predicted gene 16083 Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene STARR-positive B cell enhancer mm9_chr1:132472703-132473004 Neighboring gene STARR-seq mESC enhancer starr_02199 Neighboring gene predicted gene, 23623 Neighboring gene STARR-seq mESC enhancer starr_02200 Neighboring gene complement component 4 binding protein Neighboring gene complement component 4 binding protein, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Function of the acrosomal matrix: zona pellucida 3 receptor (ZP3R/sp56) is not essential for mouse fertilization. Muro Y, et al. Biol Reprod, 2012 Jan. PMID 21998167, Free PMC Article
    2. Functional consequences of cleavage, dissociation and exocytotic release of ZP3R, a C4BP-related protein, from the mouse sperm acrosomal matrix. Buffone MG, et al. J Cell Sci, 2009 Sep 1. PMID 19654207, Free PMC Article
    3. Recombinant mouse sperm ZP3-binding protein (ZP3R/sp56) forms a high order oligomer that binds eggs and inhibits mouse fertilization in vitro. Buffone MG, et al. J Biol Chem, 2008 May 2. PMID 18316377, Free PMC Article
    4. Sperm-egg recognition in the mouse: characterization of sp56, a sperm protein having specific affinity for ZP3. Cheng A, et al. J Cell Biol, 1994 May. PMID 8188752, Free PMC Article
    5. Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc(-/-) globozoospermic spermatogenesis. Bizkarguenaga M, et al. Microsc Res Tech, 2022 Apr. PMID 34870349

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc(-/-) globozoospermic spermatogenesis.
      Title: Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc(-/-) globozoospermic spermatogenesis.
    2. These results provide further evidence that either ZP3R is not involved in sperm-zona pellucida binding or this process might be functionally redundant, involving multiple proteins for gamete interactions.
      Title: Function of the acrosomal matrix: zona pellucida 3 receptor (ZP3R/sp56) is not essential for mouse fertilization.
    3. ZP3R monomer is processed from 67,000 M(r) to 43,000 M(r) by proteases coincident with release from the acrosome.
      Title: Functional consequences of cleavage, dissociation and exocytotic release of ZP3R, a C4BP-related protein, from the mouse sperm acrosomal matrix.
    4. These results indicate that sperm ZP3R/sp56 is important for sperm-zona interactions during fertilization and support the concept that the acrosomal matrix plays an essential role in mediating the binding of sperm to the zona pellucida.
      Title: Recombinant mouse sperm ZP3-binding protein (ZP3R/sp56) forms a high order oligomer that binds eggs and inhibits mouse fertilization in vitro.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of opsonization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to symbiotic bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within single fertilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal vesicle EXP
    Inferred from Experiment
    more info
    		 PubMed 
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in outer acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of zona pellucida receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zona pellucida sperm-binding protein 3 receptor
    Names
    sperm fertilization protein 56

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420657.1 → NP_001407586.1  zona pellucida sperm-binding protein 3 receptor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC122773
      UniProtKB/Swiss-Prot
      Q60736
      UniProtKB/TrEMBL
      Q0VET1
      Related
      ENSMUSP00000114401.2, ENSMUST00000128128.8

    2. NM_009581.3 → NP_033607.2  zona pellucida sperm-binding protein 3 receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_033607.2

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC122773
      Consensus CDS
      CCDS15257.1
      UniProtKB/Swiss-Prot
      Q60736
      UniProtKB/TrEMBL
      G3X970, Q0VET1
      Related
      ENSMUSP00000045443.5, ENSMUST00000039862.11
      Conserved Domains (4) summary
      cd00033
      Location:158 → 219
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:350 → 411
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:153 → 411
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:283 → 343
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130474847..130557371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247992.3 → XP_011246294.1  zona pellucida sperm-binding protein 3 receptor isoform X2

      Conserved Domains (3) summary
      smart00032
      Location:371 → 432
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:71 → 299
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:304 → 364
      Sushi; Sushi repeat (SCR repeat)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60736.1 GenPept UniProtKB/Swiss-Prot:Q60736

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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