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    Ikzf5 IKAROS family zinc finger 5 [ Mus musculus (house mouse) ]

    Gene ID: 67143, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ikzf5provided by MGI
    Official Full Name
    IKAROS family zinc finger 5provided by MGI
    Primary source
    MGI:MGI:1914393
    See related
    Ensembl:ENSMUSG00000040167 AllianceGenome:MGI:1914393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PEGASUS; Zfpn1a5; 2610034F18Rik
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Is expressed in several structures, including eye; genitourinary system; gut; integumental system; and nervous system. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 6.4), liver E14.5 (RPKM 5.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ikzf5 in Genome Data Viewer
    Location:
    7 F3; 7 73.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (130990378..131012243, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131388649..131410518, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310057M21 gene Neighboring gene family with sequence similarity 24, member A Neighboring gene STARR-positive B cell enhancer ABC_E9713 Neighboring gene STARR-positive B cell enhancer ABC_E8214 Neighboring gene STARR-seq mESC enhancer starr_20280 Neighboring gene phosphoseryl-tRNA kinase Neighboring gene STARR-seq mESC enhancer starr_20281 Neighboring gene STARR-positive B cell enhancer ABC_E4981 Neighboring gene acyl-Coenzyme A dehydrogenase, short/branched chain Neighboring gene motile sperm domain containing 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Quick validation of genetic quality for conditional alleles in mice. Nakata H, et al. Genes Cells, 2021 Apr. PMID 33540482, Free PMC Article
    2. Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. Yeung F, et al. Nucleic Acids Res, 2012 Aug. PMID 22638570, Free PMC Article
    3. Ikaros confers early temporal competence to mouse retinal progenitor cells. Elliott J, et al. Neuron, 2008 Oct 9. PMID 18940586
    4. Ikaros promotes early-born neuronal fates in the cerebral cortex. Alsiö JM, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382203, Free PMC Article
    5. Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons. Martín-Ibáñez R, et al. Development, 2017 Apr 15. PMID 28289129, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106439

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein Pegasus
    Names
    ikaros family zinc finger protein 5
    zinc finger protein, subfamily 1A, 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418761.1 → NP_001405690.1  zinc finger protein Pegasus isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156606

    2. NM_001418762.1 → NP_001405691.1  zinc finger protein Pegasus isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156606
      Related
      ENSMUSP00000113714.2, ENSMUST00000121033.8

    3. NM_001418763.1 → NP_001405692.1  zinc finger protein Pegasus isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156606
      UniProtKB/Swiss-Prot
      Q3U549, Q3USG0, Q8BU00, Q8BZR5

    4. NM_175115.5 → NP_780324.2  zinc finger protein Pegasus isoform 1

      See identical proteins and their annotated locations for NP_780324.2

      Status: VALIDATED

      Source sequence(s)
      AC156606
      Consensus CDS
      CCDS21915.1
      UniProtKB/Swiss-Prot
      Q3U549, Q3USG0, Q8BU00, Q8BZR5
      Related
      ENSMUSP00000035583.9, ENSMUST00000046306.15
      Conserved Domains (4) summary
      sd00017
      Location:84 → 104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:366 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:124 → 148
      zf-H2C2_2; Zinc-finger double domain
      NF033913
      Location:216 → 352
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      130990378..131012243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153377.1 → XP_036009270.1  zinc finger protein Pegasus isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:45 → 65
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:57 → 81
      zf-H2C2_2; Zinc-finger double domain
      NF033913
      Location:149 → 285
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    2. XM_036153376.1 → XP_036009269.1  zinc finger protein Pegasus isoform X1

      UniProtKB/Swiss-Prot
      Q3U549, Q3USG0, Q8BU00, Q8BZR5
      Conserved Domains (4) summary
      sd00017
      Location:84 → 104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:366 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:124 → 148
      zf-H2C2_2; Zinc-finger double domain
      NF033913
      Location:216 → 352
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BU00.1 GenPept UniProtKB/Swiss-Prot:Q8BU00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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