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    Slc25a43 solute carrier family 25, member 43 [ Mus musculus (house mouse) ]

    Gene ID: 194744, updated on 9-May-2024

    Summary

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    Official Symbol
    Slc25a43provided by MGI
    Official Full Name
    solute carrier family 25, member 43provided by MGI
    Primary source
    MGI:MGI:2684854
    See related
    Ensembl:ENSMUSG00000037636 AllianceGenome:MGI:2684854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm8
    Summary
    Predicted to be involved in transmembrane transport. Located in mitochondrion. Orthologous to human SLC25A43 (solute carrier family 25 member 43). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 1.9), ovary adult (RPKM 0.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a43 in Genome Data Viewer
    Location:
    X A3.3; X 21.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36007223..36040960)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36743570..36777307)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46998 Neighboring gene ribosomal protein L7, pseudogene 9 Neighboring gene predicted gene, 57674 Neighboring gene STARR-seq mESC enhancer starr_46999 Neighboring gene STARR-seq mESC enhancer starr_47000 Neighboring gene STARR-seq mESC enhancer starr_47001 Neighboring gene predicted gene, 23613 Neighboring gene STARR-seq mESC enhancer starr_47002 Neighboring gene solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Neighboring gene STARR-seq mESC enhancer starr_47003 Neighboring gene mitochondrial dynamic related lncRNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    solute carrier family 25 member 43
    Names
    mitochondrial solute carrier protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085497.2 → NP_001078966.1  solute carrier family 25 member 43

      See identical proteins and their annotated locations for NP_001078966.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      BC147709
      Consensus CDS
      CCDS40925.1
      UniProtKB/Swiss-Prot
      A2A3V2, B2RWC0
      Related
      ENSMUSP00000035392.7, ENSMUST00000047655.7
      Conserved Domains (1) summary
      pfam00153
      Location:102 → 185
      Mito_carr; Mitochondrial carrier protein

    RNA

    1. NR_075096.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC172137

    2. NR_075097.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC147709

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      36007223..36040960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541378.3 → XP_006541441.1  solute carrier family 25 member 43 isoform X1

      Conserved Domains (2) summary
      PTZ00169
      Location:17 → 229
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:107 → 185
      Mito_carr; Mitochondrial carrier protein

    2. XM_006541379.3 → XP_006541442.1  solute carrier family 25 member 43 isoform X2

      Conserved Domains (2) summary
      PTZ00169
      Location:17 → 237
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:107 → 185
      Mito_carr; Mitochondrial carrier protein

    3. XM_006541381.4 → XP_006541444.1  solute carrier family 25 member 43 isoform X4

      Conserved Domains (2) summary
      PTZ00169
      Location:17 → 229
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:107 → 185
      Mito_carr; Mitochondrial carrier protein

    4. XM_006541380.4 → XP_006541443.1  solute carrier family 25 member 43 isoform X3

      Conserved Domains (2) summary
      PTZ00169
      Location:17 → 229
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:107 → 185
      Mito_carr; Mitochondrial carrier protein

    RNA

    1. XR_391662.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A3V2.1 GenPept UniProtKB/Swiss-Prot:A2A3V2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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