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    Atg2a autophagy related 2A [ Mus musculus (house mouse) ]

    Gene ID: 329015, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Atg2aprovided by MGI
    Official Full Name
    autophagy related 2Aprovided by MGI
    Primary source
    MGI:MGI:1916291
    See related
    Ensembl:ENSMUSG00000024773 AllianceGenome:MGI:1916291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0404; A830054M12; 1810013C15Rik
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion; autophagy of nucleus; and macroautophagy. Predicted to be located in endoplasmic reticulum; lipid droplet; and membrane. Predicted to be active in phagophore assembly site. Predicted to be extrinsic component of membrane. Orthologous to human ATG2A (autophagy related 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 34.8), thymus adult (RPKM 26.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atg2a in Genome Data Viewer
    Location:
    19 A; 19 4.37 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6291508..6312332)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6241478..6262304)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene membrane anchored junction protein Neighboring gene protein phosphatase 2, regulatory subunit B', beta Neighboring gene glycoprotein hormone alpha 2 Neighboring gene STARR-positive B cell enhancer ABC_E9990 Neighboring gene STARR-positive B cell enhancer ABC_E5681 Neighboring gene STARR-positive B cell enhancer ABC_E619 Neighboring gene microRNA 194-2 Neighboring gene microRNA 192

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans. Nicola AM, et al. Infect Immun, 2012 Sep. PMID 22710871, Free PMC Article
    2. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Sincennes MC, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26764384, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC67447

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in phagophore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    autophagy-related protein 2 homolog A
    Names
    ATG2 autophagy related 2 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408280.1 → NP_001395209.1  autophagy-related protein 2 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127556
      Related
      ENSMUSP00000114998.2, ENSMUST00000145600.2

    2. NM_001408281.1 → NP_001395210.1  autophagy-related protein 2 homolog A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127556

    3. NM_194348.4 → NP_919329.2  autophagy-related protein 2 homolog A isoform 2

      See identical proteins and their annotated locations for NP_919329.2

      Status: VALIDATED

      Source sequence(s)
      AC127556
      Consensus CDS
      CCDS29500.1
      UniProtKB/Swiss-Prot
      Q3U9I1, Q6P4T0, Q6PHN0, Q6ZQC4, Q8R213
      UniProtKB/TrEMBL
      F6V3Y9
      Related
      ENSMUSP00000046412.7, ENSMUST00000045351.13
      Conserved Domains (2) summary
      pfam09333
      Location:1815 → 1908
      ATG_C; Autophagy-related protein C terminal domain
      pfam12624
      Location:14 → 111
      Chorein_N; N-terminal region of Chorein or VPS13

    RNA

    1. NR_176623.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127556

    2. NR_176624.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127556

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6291508..6312332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531773.4 → XP_006531836.1  autophagy-related protein 2 homolog A isoform X2

      Conserved Domains (1) summary
      pfam09333
      Location:1082 → 1175
      ATG_C; Autophagy-related protein C terminal domain

    2. XM_006531774.5 → XP_006531837.1  autophagy-related protein 2 homolog A isoform X3

      Conserved Domains (1) summary
      pfam09333
      Location:976 → 1069
      ATG_C; Autophagy-related protein C terminal domain

    3. XM_006531775.5 → XP_006531838.1  autophagy-related protein 2 homolog A isoform X4

      Conserved Domains (1) summary
      pfam09333
      Location:931 → 1024
      ATG_C; Autophagy-related protein C terminal domain

    RNA

    1. XR_004940153.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4T0.2 GenPept UniProtKB/Swiss-Prot:Q6P4T0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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