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    Muc17 mucin 17, cell surface associated [ Mus musculus (house mouse) ]

    Gene ID: 666339, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Muc17provided by MGI
    Official Full Name
    mucin 17, cell surface associatedprovided by MGI
    Primary source
    MGI:MGI:1203527
    See related
    Ensembl:ENSMUSG00000037390 AllianceGenome:MGI:1203527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Muc3
    Summary
    Predicted to enable PDZ domain binding activity. Located in apical plasma membrane and microvillus. Is expressed in bladder; testis; and ureter. Orthologous to human MUC17 (mucin 17, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 3121.3), small intestine adult (RPKM 1038.7) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Muc17 in Genome Data Viewer
    Location:
    5 G2; 5 76.22 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137163772..137202809, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137134924..137166048, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 1 Neighboring gene STARR-seq mESC enhancer starr_14636 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137579031-137579214 Neighboring gene tripartite motif-containing 56 Neighboring gene predicted gene, 40348 Neighboring gene predicted gene, 31160 Neighboring gene peptidyl-prolyl cis-trans isomerase G-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues. Ashton KJ, et al. J Mol Cell Cardiol, 2007 Apr. PMID 17258765
    2. Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokines. Shekels LL, et al. Biochim Biophys Acta, 2003 Jun 19. PMID 12818427
    3. Study of mucin turnover in the small intestine by in vivo labeling. Schneider H, et al. Sci Rep, 2018 Apr 10. PMID 29636525, Free PMC Article
    4. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Cao E, et al. Immunity, 2007 Mar. PMID 17363302
    5. C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components. Wang R, et al. Biochem J, 2002 Sep 1. PMID 12027806, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Muc17 (= Muc3) showed stable expression over time at the plasma membrane on villi tips, in crypts and at crypt openings. (In humans: Muc3 = Muc17)
      Title: Study of mucin turnover in the small intestine by in vivo labeling.
    2. Butyrate enemas upregulate Muc3 gene expression but decrease adherent mucus thickness in mice colon.
      Title: Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon.
    3. the expression of mucins 1 to 4 and trefoil factor 3 was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals
      Title: Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota.
    4. C-terminal domain is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components
      Title: C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components.
    5. These data indicate that cytokines and growth factors are capable of regulating Muc3 gene expression, suggesting that this protein may play an active role in intestinal mucosal defense.
      Title: Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokines.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mucin-17
    Names
    mucin 3, intestinal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010843.2 → NP_034973.2  mucin-17 precursor

      Status: VALIDATED

      Source sequence(s)
      AC242397, MG954266
      UniProtKB/TrEMBL
      E9PWP7
      Related
      ENSMUSP00000045196.11, ENSMUST00000041226.11
      Conserved Domains (1) summary
      smart00200
      Location:4185 → 4296
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137163772..137202809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165418.1 → XP_036021311.1  mucin-17 isoform X7

      Conserved Domains (1) summary
      smart00200
      Location:3717 → 3828
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    2. XM_036165414.1 → XP_036021307.1  mucin-17 isoform X3

      Conserved Domains (1) summary
      smart00200
      Location:3765 → 3876
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    3. XM_036165421.1 → XP_036021314.1  mucin-17 isoform X10

      Conserved Domains (1) summary
      smart00200
      Location:3693 → 3804
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    4. XM_036165416.1 → XP_036021309.1  mucin-17 isoform X5

      Conserved Domains (1) summary
      smart00200
      Location:3741 → 3852
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    5. XM_036165422.1 → XP_036021315.1  mucin-17 isoform X11

      Conserved Domains (1) summary
      smart00200
      Location:3681 → 3792
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    6. XM_036165415.1 → XP_036021308.1  mucin-17 isoform X4

      Conserved Domains (1) summary
      smart00200
      Location:3759 → 3870
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    7. XM_036165420.1 → XP_036021313.1  mucin-17 isoform X9

      Conserved Domains (1) summary
      smart00200
      Location:3711 → 3822
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    8. XM_036165424.1 → XP_036021317.1  mucin-17 isoform X13

      Conserved Domains (1) summary
      smart00200
      Location:3392 → 3503
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    9. XM_036165425.1 → XP_036021318.1  mucin-17 isoform X14

      Conserved Domains (1) summary
      smart00200
      Location:3356 → 3467
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    10. XM_036165417.1 → XP_036021310.1  mucin-17 isoform X6

      Conserved Domains (1) summary
      smart00200
      Location:3741 → 3852
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    11. XM_036165412.1 → XP_036021305.1  mucin-17 isoform X1

      Conserved Domains (1) summary
      smart00200
      Location:3789 → 3900
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    12. XM_036165423.1 → XP_036021316.1  mucin-17 isoform X12

      Conserved Domains (1) summary
      smart00200
      Location:3579 → 3690
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    13. XM_036165413.1 → XP_036021306.1  mucin-17 isoform X2

      Conserved Domains (1) summary
      smart00200
      Location:3789 → 3900
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    14. XM_036165427.1 → XP_036021320.1  mucin-17 isoform X16

      Conserved Domains (1) summary
      smart00200
      Location:2288 → 2399
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    15. XM_036165426.1 → XP_036021319.1  mucin-17 isoform X15

      Conserved Domains (1) summary
      smart00200
      Location:3236 → 3347
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    16. XM_036165419.1 → XP_036021312.1  mucin-17 isoform X8

      Conserved Domains (1) summary
      smart00200
      Location:3711 → 3822
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    Nucleotide Protein Strain
    Heading Accession and Version

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