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    Upk3bl uroplakin 3B-like [ Mus musculus (house mouse) ]

    Gene ID: 69665, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Upk3blprovided by MGI
    Official Full Name
    uroplakin 3B-likeprovided by MGI
    Primary source
    MGI:MGI:1916915
    See related
    Ensembl:ENSMUSG00000006143 AllianceGenome:MGI:1916915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Upk3bl1; 2310043J07Rik
    Summary
    Predicted to enable heme binding activity and peroxidase activity. Predicted to be involved in response to oxidative stress. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system. Orthologous to several human genes including UPK3BL1 (uroplakin 3B like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 15.0), CNS E18 (RPKM 1.3) and 2 other tissues See more
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    Genomic context

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    See Upk3bl in Genome Data Viewer
    Location:
    5 G2; 5 75.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136086114..136105549)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136057259..136076695)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene deltex 2, E3 ubiquitin ligase Neighboring gene uroplakin 3B Neighboring gene predicted gene, 40347 Neighboring gene STARR-positive B cell enhancer ABC_E2768 Neighboring gene STARR-seq mESC enhancer starr_14614 Neighboring gene RAS p21 protein activator 4 Neighboring gene microRNA 7035 Neighboring gene STARR-positive B cell enhancer ABC_E856 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide J

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uroplakin-3b-like protein 1
    Names
    uroplakin-3-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359361.1 → NP_001346290.1  uroplakin-3b-like protein 1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC087420, BC115564
      UniProtKB/Swiss-Prot
      A0AUM6, Q4KL12, Q9D701
      UniProtKB/TrEMBL
      F6X493
      Related
      ENSMUSP00000123311.3, ENSMUST00000156530.8
      Conserved Domains (1) summary
      cl06408
      Location:28 → 201
      UP_III_II; Uroplakin IIIb, IIIa and II

    2. NM_027158.1 → NP_081434.1  uroplakin-3b-like protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC115563, BX638176
      Consensus CDS
      CCDS51665.1
      UniProtKB/TrEMBL
      F6X493, F8WJ60
      Related
      ENSMUSP00000006303.5, ENSMUST00000006303.11
      Conserved Domains (1) summary
      cl06408
      Location:28 → 201
      UP_III_II; Uroplakin IIIb, IIIa and II

    RNA

    1. NR_153102.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC087420
      Related
      ENSMUST00000111137.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      136086114..136105549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240906.4 → XP_011239208.1  uroplakin-3b-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011239208.1

      Conserved Domains (1) summary
      cl06408
      Location:28 → 201
      UP_III_II; Uroplakin IIIb, IIIa and II

    2. XM_006504495.4 → XP_006504558.2  uroplakin-3b-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006504558.2

      Conserved Domains (1) summary
      cl06408
      Location:28 → 201
      UP_III_II; Uroplakin IIIb, IIIa and II

    RNA

    1. XR_377114.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D701.1 GenPept UniProtKB/Swiss-Prot:Q9D701

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