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    Zfp467 zinc finger protein 467 [ Mus musculus (house mouse) ]

    Gene ID: 68910, updated on 9-May-2024

    Summary

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    Official Symbol
    Zfp467provided by MGI
    Official Full Name
    zinc finger protein 467provided by MGI
    Primary source
    MGI:MGI:1916160
    See related
    Ensembl:ENSMUSG00000068551 AllianceGenome:MGI:1916160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EZI; Znf467; MNCb-3350; 1190001I08Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in cerebellum internal granule cell layer; male reproductive system; and urinary system. Orthologous to human ZNF467 (zinc finger protein 467). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 24.5), adrenal adult (RPKM 24.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp467 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.39 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48404626..48422926, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48427692..48445992, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 16630 Neighboring gene KRAB-A domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr6:48394046-48394347 Neighboring gene predicted gene, 38803 Neighboring gene predicted gene, 57777 Neighboring gene SCO-spondin Neighboring gene zinc finger protein 862, pseudogene Neighboring gene ribosomal protein L35a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zinc finger protein 467 regulates Wnt signaling by modulating the expression of sclerostin in adipose derived stem cells. You L, et al. Biochem Biophys Res Commun, 2015 Jan 9. PMID 25490389
    2. Suppression of zinc finger protein 467 alleviates osteoporosis through promoting differentiation of adipose derived stem cells to osteoblasts. You L, et al. J Transl Med, 2012 Jan 17. PMID 22252242, Free PMC Article
    3. The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche. Le PT, et al. Bone, 2021 Mar. PMID 33359894, Free PMC Article
    4. Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment. Quach JM, et al. J Biol Chem, 2011 Feb 11. PMID 21123171, Free PMC Article
    5. PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner. Liu H, et al. Elife, 2023 Apr 26. PMID 37159501, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner.
      Title: PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner.
    2. these results indicate that Zfp467 regulates the differentiation of adipose-derived stem cells via a mechanism involving Sost-mediated inhibition of Wnt signaling, suggesting potential therapeutic targets for the treatment of osteoporosis.
      Title: Zinc finger protein 467 regulates Wnt signaling by modulating the expression of sclerostin in adipose derived stem cells.
    3. Zfp467 play an important role in adipose derived stem cells differentiation to adipocyte and osteoblast.
      Title: Suppression of zinc finger protein 467 alleviates osteoporosis through promoting differentiation of adipose derived stem cells to osteoblasts.
    4. Zfp467 is a novel co-factor that promotes adipocyte differentiation and suppresses osteoblast differentiation
      Title: Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment.
    5. EZI. EZI is a novel nuclear zinc finger protein that augments STAT3 activity by keeping it in the nucleus.
      Title: A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 467
    Names
    endothelial cell-derived zinc finger protein
    zinc finger protein EZI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085415.1 → NP_001078884.1  zinc finger protein 467 isoform a

      See identical proteins and their annotated locations for NP_001078884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a distinct 5' UTR, compared to variant 1. Both variants 1 and 2 encode the longest isoform (a).
      Source sequence(s)
      AK032551, AK033146, BQ571818, BY661825
      Consensus CDS
      CCDS51764.1
      UniProtKB/Swiss-Prot
      Q8JZL0, Q9JJ98
      UniProtKB/TrEMBL
      B2RU53
      Related
      ENSMUSP00000110207.2, ENSMUST00000114560.8
      Conserved Domains (2) summary
      COG5048
      Location:190 → 564
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001085416.1 → NP_001078885.1  zinc finger protein 467 isoform b

      See identical proteins and their annotated locations for NP_001078885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a distinct 5' UTR and uses an alternate splice site, compared to variant 1, that results in a frameshift. The resulting protein (isoform b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK032551, AK033146, BY661825
      Consensus CDS
      CCDS51765.1
      UniProtKB/TrEMBL
      D3Z7M0, G3X9X3
      Related
      ENSMUSP00000110206.2, ENSMUST00000114559.8

    3. NM_001085417.1 → NP_001078886.1  zinc finger protein 467 isoform c

      See identical proteins and their annotated locations for NP_001078886.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' exon, compared to variant 1. The resulting protein (isoform c) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI552311, AK140205, BE448817, BQ175111
      Consensus CDS
      CCDS51763.1
      UniProtKB/TrEMBL
      D3Z7L9, Q3USQ2
      Related
      ENSMUSP00000098986.4, ENSMUST00000101443.10

    4. NM_001355746.1 → NP_001342675.1  zinc finger protein 467 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site, compared to variant 1, that results in a frameshift. The resulting protein (isoform b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC153815, BY661825
      Consensus CDS
      CCDS51765.1
      UniProtKB/TrEMBL
      D3Z7M0, G3X9X3
      Related
      ENSMUSP00000110205.2, ENSMUST00000114558.8

    5. NM_001355747.1 → NP_001342676.1  zinc finger protein 467 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an internal exon and uses an alternate splice site, compared to variant 1, that results in a frameshift. The resulting protein (isoform d) has a shorter N-terminus and a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC153815, BY661825
      Consensus CDS
      CCDS90044.1
      UniProtKB/TrEMBL
      D3Z7M1
      Related
      ENSMUSP00000110203.2, ENSMUST00000114556.2

    6. NM_020589.2 → NP_065614.2  zinc finger protein 467 isoform a

      See identical proteins and their annotated locations for NP_065614.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the longest isoform (a).
      Source sequence(s)
      AI552311, AK032551, AK033146, BE448817, BQ571818, BY661825, CK791410
      Consensus CDS
      CCDS51764.1
      UniProtKB/Swiss-Prot
      Q8JZL0, Q9JJ98
      UniProtKB/TrEMBL
      B2RU53
      Related
      ENSMUSP00000110208.3, ENSMUST00000114561.9
      Conserved Domains (2) summary
      COG5048
      Location:190 → 564
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48404626..48422926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255582.1 → XP_030111442.1  zinc finger protein 467 isoform X8

      UniProtKB/TrEMBL
      D3Z7L9, Q3USQ2

    2. XM_006506548.5 → XP_006506611.1  zinc finger protein 467 isoform X6

    3. XM_036152284.1 → XP_036008177.1  zinc finger protein 467 isoform X8

      UniProtKB/TrEMBL
      D3Z7L9, Q3USQ2

    4. XM_006506550.5 → XP_006506613.1  zinc finger protein 467 isoform X8

      See identical proteins and their annotated locations for XP_006506613.1

      UniProtKB/TrEMBL
      D3Z7L9, Q3USQ2
      Related
      ENSMUSP00000110213.2, ENSMUST00000114566.8

    5. XM_006506544.1 → XP_006506607.1  zinc finger protein 467 isoform X1

      See identical proteins and their annotated locations for XP_006506607.1

      Conserved Domains (2) summary
      COG5048
      Location:171 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:199 → 219
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_006506547.3 → XP_006506610.1  zinc finger protein 467 isoform X4

      See identical proteins and their annotated locations for XP_006506610.1

      Conserved Domains (4) summary
      COG5048
      Location:68 → 389
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:16 → 36
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:14 → 36
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:28 → 53
      zf-H2C2_2; Zinc-finger double domain

    7. XM_030255581.2 → XP_030111441.1  zinc finger protein 467 isoform X5

      UniProtKB/TrEMBL
      D3Z7M1

    8. XM_030255577.2 → XP_030111437.1  zinc finger protein 467 isoform X1

      Conserved Domains (2) summary
      COG5048
      Location:171 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:199 → 219
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_006506549.5 → XP_006506612.1  zinc finger protein 467 isoform X7

    10. XM_011241450.4 → XP_011239752.1  zinc finger protein 467 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:213 → 587
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. XM_030255579.2 → XP_030111439.1  zinc finger protein 467 isoform X3

      UniProtKB/Swiss-Prot
      Q8JZL0, Q9JJ98
      UniProtKB/TrEMBL
      B2RU53
      Conserved Domains (2) summary
      COG5048
      Location:190 → 564
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. XM_030255578.2 → XP_030111438.1  zinc finger protein 467 isoform X3

      UniProtKB/Swiss-Prot
      Q8JZL0, Q9JJ98
      UniProtKB/TrEMBL
      B2RU53
      Conserved Domains (2) summary
      COG5048
      Location:190 → 564
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. XM_006506545.5 → XP_006506608.1  zinc finger protein 467 isoform X1

      See identical proteins and their annotated locations for XP_006506608.1

      Conserved Domains (2) summary
      COG5048
      Location:171 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:199 → 219
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZL0.1 GenPept UniProtKB/Swiss-Prot:Q8JZL0

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