Erbb3 erb-b2 receptor tyrosine kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Erbb3provided by RGD
Official Full Name: erb-b2 receptor tyrosine kinase 3provided by RGD
Primary source: RGD:69323
See related: Ensembl:ENSRNOG00000004964 AllianceGenome:RGD:69323
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: nuc-ErbB3
Summary: Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including animal organ development; cellular response to insulin stimulus; and positive regulation of glucose import. Located in nucleus and postsynaptic membrane. Biomarker of chronic obstructive pulmonary disease and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 239.0), Liver (RPKM 205.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1579079..1600379, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (994549..1015876, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (2989202..3010610, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differentially expressed genes accompanying neurobehavioral deficits in a modified rat model of vascular dementia.
Title: Differentially expressed genes accompanying neurobehavioral deficits in a modified rat model of vascular dementia.
Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3.
Title: Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3.
Treatment of neonatal rats with rhNRG-1 induced a signaling response comparable with that observed in vitro, including increased ErbB4-pTyr(1284), Akt-pThr(308) and Erk1/2-pThr(202)/Tyr(204).
Title: Neuregulin-1 triggers GLUT4 translocation and enhances glucose uptake independently of insulin receptor substrate and ErbB3 in neonatal rat cardiomyocytes.
While no changes occur for ErbB2, ErbB4 and Nrg1, an increase of ErbB3 expression occurs after I/R injury, with and without PostC.
Title: Myocardial ischemia/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress.
NTAK/NRG2 secreted from astrocytes bound to ErbB3 on neurons, and promoted neuronal survival and neurite extension in vitro.
Title: NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3.
Sox2 promotes satellite glial cell survival through the MAPK pathway via Erbb2-Erbb3 receptors.
Title: Sox2 promotes survival of satellite glial cells in vitro.
we demonstrated the involvement of ErbB receptors in the regulation of neurite elongation and sodium current induction in PC12 cells
Title: ErbB receptors and PKC regulate PC12 neuronal-like differentiation and sodium current elicitation.
neuregulin successfully improves axo-glial interaction by speeding Sc migration via the erbB2/3-FAK pathway
Title: Neuregulin facilitates nerve regeneration by speeding Schwann cell migration via ErbB2/3-dependent FAK pathway.
Binding of L1CAM to erbB enhances its response to neuregulins.
Title: L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling.
Alternative transcription initiation results in the formation of a nuclear variant of ErbB3 in rat primary Schwann cells.
Title: A nuclear variant of ErbB3 receptor tyrosine kinase regulates ezrin distribution and Schwann cell myelination.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Erbb3 (e-PCR), detects polymorphism
- UniSTS:143004

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ErbB-3 class receptor binding	IEA Inferred from Electronic Annotation more info
enables ErbB-3 class receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neuregulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuregulin binding	IEA Inferred from Electronic Annotation more info
enables neuregulin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuregulin binding	ISO Inferred from Sequence Orthology more info
enables neuregulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables neuregulin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuregulin receptor activity	IEA Inferred from Electronic Annotation more info
enables neuregulin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuregulin receptor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERBB signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB2-ERBB3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB2-ERBB3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell development	IEA Inferred from Electronic Annotation more info
involved_in Schwann cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Schwann cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in cranial nerve development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cranial nerve development	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocardial cushion development	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in mammary gland involution	IEP Inferred from Expression Pattern more info	PubMed
involved_in motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelination	IEA Inferred from Electronic Annotation more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peripheral nervous system development	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in tongue development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of ERBB3:ERBB2 complex	IEA Inferred from Electronic Annotation more info
part_of ERBB3:ERBB2 complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor tyrosine-protein kinase erbB-3

Names: avian erythroblastosis oncogene B 3; c-erbB-3; c-erbB3; proto-oncogene-like protein c-ErbB-3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

NP_058914.2

EC 2.7.10.1

XP_017450189.1

EC 2.7.10.1

XP_017450191.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017218.3 → NP_058914.2 receptor tyrosine-protein kinase erbB-3 precursor

See identical proteins and their annotated locations for NP_058914.2

Status: PROVISIONAL

Source sequence(s)

U29339

UniProtKB/Swiss-Prot

Q62799, Q62955

UniProtKB/TrEMBL

A0A8I6A5T9

Related

ENSRNOP00000006796.3, ENSRNOT00000006796.5

Conserved Domains (8) summary

cd12095
Location:638 → 674

TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase

smart00261
Location:548 → 592

FU; Furin-like repeats

cd00064
Location:226 → 266

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:179 → 329

Furin-like; Furin-like cysteine rich region

pfam01030
Location:353 → 474

Recep_L_domain; Receptor L domain

pfam07714
Location:707 → 963

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:499 → 630

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:699 → 977

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1579079..1600379 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594700.3 → XP_017450189.1 receptor tyrosine-protein kinase erbB-3 isoform X1

UniProtKB/TrEMBL

A0A8I6A5T9, A6KSF8, G3V6N1

Conserved Domains (8) summary

cd12095
Location:638 → 674

TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase

smart00261
Location:548 → 592

FU; Furin-like repeats

cd00064
Location:226 → 266

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:179 → 329

Furin-like; Furin-like cysteine rich region

pfam01030
Location:353 → 474

Recep_L_domain; Receptor L domain

pfam07714
Location:707 → 963

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:499 → 630

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:699 → 977

PKc_like; Protein Kinases, catalytic domain
XM_017594702.3 → XP_017450191.1 receptor tyrosine-protein kinase erbB-3 isoform X2

UniProtKB/TrEMBL

A0A8I6A5T9