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    Slc16a7 solute carrier family 16 (monocarboxylic acid transporters), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 20503, updated on 12-May-2024

    Summary

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    Official Symbol
    Slc16a7provided by MGI
    Official Full Name
    solute carrier family 16 (monocarboxylic acid transporters), member 7provided by MGI
    Primary source
    MGI:MGI:1330284
    See related
    Ensembl:ENSMUSG00000020102 AllianceGenome:MGI:1330284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mct2; 4921534N07Rik; 9030411M13Rik; D630004K10Rik
    Summary
    Predicted to enable lactate transmembrane transporter activity and pyruvate transmembrane transporter activity. Predicted to be involved in plasma membrane lactate transport and pyruvate transmembrane transport. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Orthologous to human SLC16A7 (solute carrier family 16 member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 38.6), bladder adult (RPKM 5.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc16a7 in Genome Data Viewer
    Location:
    10 D3; 10 72.31 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (125055139..125225455, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (125219270..125389586, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28154 Neighboring gene STARR-seq mESC enhancer starr_28155 Neighboring gene predicted gene, 36771 Neighboring gene predicted gene, 46205 Neighboring gene STARR-seq mESC enhancer starr_28157 Neighboring gene STARR-seq mESC enhancer starr_28158 Neighboring gene STARR-seq mESC enhancer starr_28160 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene predicted gene, 40795

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Light-intensity exercise improves memory dysfunction with the restoration of hippocampal MCT2 and miRNAs in type 2 diabetic mice. Shima T, et al. Metab Brain Dis, 2023 Jan. PMID 36370225
    2. The distribution and density of monocarboxylate transporter 2 in cerebral cortex, hippocampus and cerebellum of wild-type mice. Pang R, et al. J Anat, 2020 Feb. PMID 31713246, Free PMC Article
    3. Brain-derived neurotrophic factor enhances the hippocampal expression of key postsynaptic proteins in vivo including the monocarboxylate transporter MCT2. Robinet C, et al. Neuroscience, 2011 Sep 29. PMID 21736920
    4. Alternative promoter usage and alternative splicing contribute to mRNA heterogeneity of mouse monocarboxylate transporter 2. Zhang SX, et al. Physiol Genomics, 2007 Dec 19. PMID 17911380
    5. Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway. Chenal J, et al. J Neurochem, 2007 Jul. PMID 17394554

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Light-intensity exercise improves memory dysfunction with the restoration of hippocampal MCT2 and miRNAs in type 2 diabetic mice.
      Title: Light-intensity exercise improves memory dysfunction with the restoration of hippocampal MCT2 and miRNAs in type 2 diabetic mice.
    2. Monocarboxylate Transporter-2 Expression Restricts Tumor Growth in a Murine Model of Lung Cancer: A Multi-Omic Analysis.
      Title: Monocarboxylate Transporter-2 Expression Restricts Tumor Growth in a Murine Model of Lung Cancer: A Multi-Omic Analysis.
    3. MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma.
      Title: MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma.
    4. The distribution and density of monocarboxylate transporter 2 in cerebral cortex, hippocampus and cerebellum of wild-type mice.
      Title: The distribution and density of monocarboxylate transporter 2 in cerebral cortex, hippocampus and cerebellum of wild-type mice.
    5. MCT2 dictates the mode of action of N-oxalylglycine (NOG) by determining its intracellular concentration
      Title: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.
    6. MCT1 and MCT2 not only play an important role in the transport of ketone bodies, but also in the modulation of brain energy metabolism under normal and ketogenic conditions.
      Title: Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters.
    7. Adipocytes promote malignant growth of mammary gland tumors with MCT2 expression via beta-hydroxybutyrate.
      Title: Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate.
    8. These results suggest that basigin has a functional role as a binding partner with MCT2 in testicular and epididymal spermatozoa.
      Title: Interaction between basigin and monocarboxylate transporter 2 in the mouse testes and spermatozoa.
    9. This study demonstrated that MCT2 was up regulation in ipsilateral site of brain afeter cerebral ischemia.
      Title: Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprograming taking place following cerebral ischemia.
    10. MCT2 distribution coupled with lactate uptake by hypothalamic neurons suggests that hypothalamic neurons control food intake using lactate to reflect changes in glucose levels.
      Title: MCT2 expression and lactate influx in anorexigenic and orexigenic neurons of the arcuate nucleus.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143699, MGC143700, MGC143718

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lactate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lactate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monocarboxylic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocarboxylic acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasma membrane lactate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane lactate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 2
    Names
    solute carrier family 16 member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358496.2 → NP_001345425.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478
      Consensus CDS
      CCDS24218.1
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Related
      ENSMUSP00000147968.2, ENSMUST00000211781.2
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    2. NM_001358915.2 → NP_001345844.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478
      Consensus CDS
      CCDS24218.1
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Related
      ENSMUSP00000100892.3, ENSMUST00000105257.4
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    3. NM_001428806.1 → NP_001415735.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478, AC153890

    4. NM_001428807.1 → NP_001415736.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478, AC153890

    5. NM_001428808.1 → NP_001415737.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478, AC153890

    6. NM_001428809.1 → NP_001415738.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478, AC153890

    7. NM_011391.3 → NP_035521.1  monocarboxylate transporter 2

      See identical proteins and their annotated locations for NP_035521.1

      Status: VALIDATED

      Source sequence(s)
      AC093478
      Consensus CDS
      CCDS24218.1
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Related
      ENSMUSP00000065433.3, ENSMUST00000063318.10
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      125055139..125225455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513406.4 → XP_006513469.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    2. XM_030244968.2 → XP_030100828.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    3. XM_006513413.5 → XP_006513476.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    4. XM_006513409.5 → XP_006513472.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    5. XM_006513410.5 → XP_006513473.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_006513473.1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Related
      ENSMUSP00000147560.2, ENSMUST00000210780.2
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    6. XM_030244969.2 → XP_030100829.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    7. XM_006513408.5 → XP_006513471.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_006513471.1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    8. XM_030244970.2 → XP_030100830.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1

    9. XM_017313861.3 → XP_017169350.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Conserved Domains (1) summary
      TIGR00892
      Location:5 → 431
      2A0113; monocarboxylate transporter 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70451.1 GenPept UniProtKB/Swiss-Prot:O70451

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