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    Adra1d adrenergic receptor, alpha 1d [ Mus musculus (house mouse) ]

    Gene ID: 11550, updated on 9-May-2024

    Summary

    Official Symbol
    Adra1dprovided by MGI
    Official Full Name
    adrenergic receptor, alpha 1dprovided by MGI
    Primary source
    MGI:MGI:106673
    See related
    Ensembl:ENSMUSG00000027335 AllianceGenome:MGI:106673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spr8; Adra1; Gpcr8; [a]1d; Adra-1; Adra1a; alpha1D-AR
    Summary
    Enables alpha1-adrenergic receptor activity. Involved in multicellular organism aging; neuron-glial cell signaling; and regulation of blood pressure. Acts upstream of or within negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure and norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure. Predicted to be located in cytosol. Predicted to be integral component of plasma membrane. Is expressed in brain; diencephalon; and forebrain. Orthologous to human ADRA1D (adrenoceptor alpha 1D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal adult (RPKM 24.0), cortex adult (RPKM 9.4) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Adra1d in Genome Data Viewer
    Location:
    2 F1; 2 63.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131387277..131404417, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131545357..131562497, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30679 Neighboring gene STARR-seq mESC enhancer starr_05713 Neighboring gene spermine oxidase Neighboring gene predicted gene, 30732 Neighboring gene predicted gene, 39938 Neighboring gene predicted gene 14285 Neighboring gene STARR-seq mESC enhancer starr_05714 Neighboring gene predicted gene 14280 Neighboring gene predicted gene, 30986

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables adrenergic receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha1-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha1-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alpha1-adrenergic receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron-glial cell signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of vasoconstriction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    alpha-1D adrenergic receptor
    Names
    alpha-1A adrenergic receptor
    alpha-1D adrenoceptor
    alpha-1D adrenoreceptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013460.5NP_038488.4  alpha-1D adrenergic receptor

      See identical proteins and their annotated locations for NP_038488.4

      Status: VALIDATED

      Source sequence(s)
      AL831731
      Consensus CDS
      CCDS16764.1
      UniProtKB/Swiss-Prot
      P97714, Q61619
      UniProtKB/TrEMBL
      A2ANQ2
      Related
      ENSMUSP00000099473.4, ENSMUST00000103184.4
      Conserved Domains (2) summary
      cd14964
      Location:93117
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:91407
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      131387277..131404417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)