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    Snhg16 small nucleolar RNA host gene 16 [ Mus musculus (house mouse) ]

    Gene ID: 66293, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Snhg16provided by MGI
    Official Full Name
    small nucleolar RNA host gene 16provided by MGI
    Primary source
    MGI:MGI:1913543
    See related
    Ensembl:ENSMUSG00000020812 AllianceGenome:MGI:1913543
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810032O08Rik
    Summary
    Orthologous to human SNHG16 (small nucleolar RNA host gene 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 8.6), CNS E11.5 (RPKM 7.0) and 28 other tissues See more
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    Genomic context

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    See Snhg16 in Genome Data Viewer
    Location:
    11 E2; 11 81.49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116562486..116566624)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116671660..116675798)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene arylalkylamine N-acetyltransferase Neighboring gene rhomboid 5 homolog 2 Neighboring gene STARR-seq mESC enhancer starr_31215 Neighboring gene STARR-seq mESC enhancer starr_31216 Neighboring gene cytoglobin Neighboring gene photoreceptor disc component Neighboring gene STARR-positive B cell enhancer ABC_E471 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Neighboring gene small nucleolar RNA, C/D box 1C Neighboring gene small nucleolar RNA, C/D box 1B Neighboring gene small nucleolar RNA, C/D box 1A Neighboring gene STARR-seq mESC enhancer starr_31219 Neighboring gene STARR-seq mESC enhancer starr_31222 Neighboring gene predicted gene 11735

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LncRNA SNHG16 induces proliferation and fibrogenesis via modulating miR-141-3p and CCND1 in diabetic nephropathy. Jiang X, et al. Gene Ther, 2020 Dec. PMID 32504027
    2. LncRNA SNHG16 promotes pulmonary fibrosis by targeting miR-455-3p to regulate the Notch2 pathway. Liu P, et al. Respir Res, 2021 Feb 6. PMID 33549106, Free PMC Article
    3. LncRNA SNHG16 regulates RAS and NF-κB pathway-mediated NLRP3 inflammasome activation to aggravate diabetes nephropathy through stabilizing TLR4. Liu Y, et al. Acta Diabetol, 2023 Apr. PMID 36658449
    4. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
    5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNHG16/miR-205/HDAC5 is involved in the progression of renal fibrosis.
      Title: SNHG16/miR-205/HDAC5 is involved in the progression of renal fibrosis.
    2. Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus.
      Title: Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus.
    3. LncRNA SNHG16 regulates RAS and NF-kappaB pathway-mediated NLRP3 inflammasome activation to aggravate diabetes nephropathy through stabilizing TLR4.
      Title: LncRNA SNHG16 regulates RAS and NF-κB pathway-mediated NLRP3 inflammasome activation to aggravate diabetes nephropathy through stabilizing TLR4.
    4. LncRNA SNHG16 promotes pulmonary fibrosis by targeting miR-455-3p to regulate the Notch2 pathway.
      Title: LncRNA SNHG16 promotes pulmonary fibrosis by targeting miR-455-3p to regulate the Notch2 pathway.
    5. LncRNA SNHG16 induces proliferation and fibrogenesis via modulating miR-141-3p and CCND1 in diabetic nephropathy.
      Title: LncRNA SNHG16 induces proliferation and fibrogenesis via modulating miR-141-3p and CCND1 in diabetic nephropathy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027819.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the most predominant transcript.
      Source sequence(s)
      AK007675, BC055707
      Related
      ENSMUST00000139934.9

    2. NR_027820.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing an internal exon at the 5' end compared to variant 1.
      Source sequence(s)
      AK007675, AK013681, BC055707
      Related
      ENSMUST00000142834.9

    3. NR_027821.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an additional segment at the 3' end compared to variant 1.
      Source sequence(s)
      AK007675, BC055707
      Related
      ENSMUST00000106378.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116562486..116566624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025472.2: Suppressed sequence

      Description
      NM_025472.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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