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    Cog4 component of oligomeric golgi complex 4 [ Mus musculus (house mouse) ]

    Gene ID: 102339, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cog4provided by MGI
    Official Full Name
    component of oligomeric golgi complex 4provided by MGI
    Primary source
    MGI:MGI:2142808
    See related
    Ensembl:ENSMUSG00000031753 AllianceGenome:MGI:2142808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D8Ertd515e
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in Golgi organization; Golgi vesicle prefusion complex stabilization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport. Predicted to be located in Golgi apparatus and membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Orthologous to human COG4 (component of oligomeric golgi complex 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 20.1), testis adult (RPKM 19.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cog4 in Genome Data Viewer
    Location:
    8 E1; 8 57.76 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111573232..111608866)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110846600..110882234)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_22685 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene predicted gene, 22193 Neighboring gene STARR-positive B cell enhancer ABC_E11398 Neighboring gene fucose kinase Neighboring gene STARR-positive B cell enhancer ABC_E9743 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 26132

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    conserved oligomeric Golgi complex subunit 4
    Names
    COG complex subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310607.1 → NP_001297536.1  conserved oligomeric Golgi complex subunit 4 isoform 2

      See identical proteins and their annotated locations for NP_001297536.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AY223866, BM226598
      Consensus CDS
      CCDS80931.1
      UniProtKB/TrEMBL
      G3UWH9, Q7TSQ9
      Related
      ENSMUSP00000128518.2, ENSMUST00000165867.8
      Conserved Domains (2) summary
      pfam04437
      Location:513 → 699
      RINT1_TIP1; RINT-1 / TIP-1 family
      pfam08318
      Location:115 → 424
      COG4; COG4 transport protein

    2. NM_133973.2 → NP_598734.1  conserved oligomeric Golgi complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_598734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer isoform (1).
      Source sequence(s)
      AY223866, BM226598, CN843612
      Consensus CDS
      CCDS40477.1
      UniProtKB/Swiss-Prot
      Q3T9K1, Q8R1U1
      UniProtKB/TrEMBL
      G3UWH9
      Related
      ENSMUSP00000034203.10, ENSMUST00000034203.17
      Conserved Domains (2) summary
      pfam04437
      Location:586 → 772
      RINT1_TIP1; RINT-1 / TIP-1 family
      pfam08318
      Location:188 → 497
      COG4; COG4 transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111573232..111608866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_387727.3 RNA Sequence

    2. XR_003947213.1 RNA Sequence

    3. XR_004934744.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1U1.1 GenPept UniProtKB/Swiss-Prot:Q8R1U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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