Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lamtor2provided by MGI
Official Full Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2provided by MGI
Primary source: MGI:MGI:1932697
See related: Ensembl:ENSMUSG00000028062 AllianceGenome:MGI:1932697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P14; Rab25; Robld3; Mapbpip; 2010111E04Rik
Summary: Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Acts upstream of or within several processes, including fibroblast migration; positive regulation of MAPK cascade; and regulation of cell-substrate junction organization. Located in late endosome. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 88.5), colon adult (RPKM 83.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.87 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88457126..88460258, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88549819..88552951, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[LAMTOR2 deficiency exacerbates Klebsiella pneumoniae-induced liver sepsis in mice].
Title: [LAMTOR2 deficiency exacerbates Klebsiella pneumoniae-induced liver sepsis in mice].
LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking.
Title: LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking.
LAMTOR2 regulates lipid metabolism in macrophages and foam cell differentiation.
Title: LAMTOR/Ragulator regulates lipid metabolism in macrophages and foam cell differentiation.
Hotair silence activates P16(Ink4a) and P14(ARF) signaling by enhancing miR-218 expression and suppressing Bmi-1 expression, resulting in the suppression of tumorigenesis in HCC.
Title: Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling.
LAMTOR2 has a role in regulating dendritic cell homeostasis through FLT3-dependent mTOR signalling
Title: LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signalling.
Lamtor2 deficiency affects TGFbeta1 sensitivity of Langerhan cells, which is mandatory for their homeostasis and subsequently for their immunological function during contact hypersensitivity.
Title: The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.
We show an essential function for late endosomes carrying the p14-MP1 (LAMTOR2/3) complex in focal adhesion dynamics.
Title: The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.
The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis.
Title: The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis.
Data indicate that LAMTOR3 protein is stabilized by associating with LAMTOR2.
Title: Stability of the endosomal scaffold protein LAMTOR3 depends on heterodimer assembly and proteasomal degradation.
The late endosomal adaptor p14 (also known as LAMTOR2) is one of the components for cellular host defense against the intracellular pathogen Salmonella enterica serovar Typhimurium.
Title: The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
contributes_to molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in TORC1 signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to amino acid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fibroblast migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cell junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell-substrate junction organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell-substrate junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell-substrate junction organization	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
part_of FNIP-folliculin RagC/D GAP	ISO Inferred from Sequence Orthology more info
part_of Ragulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ragulator complex	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	NAS Non-traceable Author Statement more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ragulator complex protein LAMTOR2

Names: endosomal adaptor protein p14; late endosomal/lysosomal MP1 interacting protein; late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; mitogen-activated protein-binding protein-interacting protein; roadblock domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362368.1 → NP_001349297.1 ragulator complex protein LAMTOR2 isoform 2

Status: VALIDATED

Source sequence(s)

BE629197, BY062676

Conserved Domains (1) summary

pfam03259
Location:8 → 77

Robl_LC7; Roadblock/LC7 domain
NM_031248.4 → NP_112538.1 ragulator complex protein LAMTOR2 isoform 1

See identical proteins and their annotated locations for NP_112538.1

Status: VALIDATED

Source sequence(s)

AA250375, BE947263, BY062676

Consensus CDS

CCDS17478.1

UniProtKB/Swiss-Prot

Q9JHS3

Related

ENSMUSP00000029698.9, ENSMUST00000029698.15

Conserved Domains (1) summary

pfam03259
Location:5 → 95

Robl_LC7; Roadblock/LC7 domain

RNA

NR_155541.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC145168
NR_155542.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC145168

Related

ENSMUST00000156421.2
NR_155543.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AW988728, BE947263, BY062676

Related

ENSMUST00000119002.2