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    Osbpl5 oxysterol binding protein-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 79196, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Osbpl5provided by MGI
    Official Full Name
    oxysterol binding protein-like 5provided by MGI
    Primary source
    MGI:MGI:1930265
    See related
    Ensembl:ENSMUSG00000037606 AllianceGenome:MGI:1930265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORP5; Obph1; Osbp2; 1110006M06Rik
    Summary
    Predicted to enable several functions, including cholesterol binding activity; phosphatidylserine transfer activity; and phospholipid binding activity. Predicted to be involved in phospholipid transport. Predicted to act upstream of or within lipid transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; immune system; and notochord. Orthologous to human OSBPL5 (oxysterol binding protein like 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 27.8), ovary adult (RPKM 26.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osbpl5 in Genome Data Viewer
    Location:
    7 F5; 7 88.29 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143242499..143310745, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143688762..143757008, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E230032D23 gene Neighboring gene STARR-seq mESC enhancer starr_20534 Neighboring gene tumor necrosis factor receptor superfamily, member 22 Neighboring gene tumor necrosis factor receptor superfamily, member 23 Neighboring gene STARR-positive B cell enhancer ABC_E10486 Neighboring gene STARR-positive B cell enhancer ABC_E2256 Neighboring gene STARR-positive B cell enhancer ABC_E3762 Neighboring gene MAS-related GPR, member G Neighboring gene MAS-related GPR, member E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse. Higashimoto K, et al. Genomics, 2002 Dec. PMID 12504849
    2. Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Yan D, et al. Arterioscler Thromb Vasc Biol, 2007 May. PMID 17303778
    3. The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface. Clark L, et al. BMC Genet, 2002 Jun 27. PMID 12102730, Free PMC Article
    4. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Schneider P, et al. J Biol Chem, 2003 Feb 14. PMID 12466268
    5. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. Laitinen S, et al. J Lipid Res, 1999 Dec. PMID 10588946

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OBPH1/Obph1 gene is imprinted, with preferential expression from the maternal allele in human and mouse.
      Title: Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse.
    2. OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis.
      Title: Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 5
    Names
    ORP-5
    OSBP-related protein 5
    oxysterol binding protein 2
    oxysterol binding protein homolog 1
    oxysterol-binding protein-like protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199227.1 → NP_001186156.1  oxysterol-binding protein-related protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001186156.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different exon at its 5' terminus which results in the use of a downstream in-frame translation initiation site, compared to variant 1. It encodes an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC079872, BY234441, EH108768
      Consensus CDS
      CCDS57598.1
      UniProtKB/Swiss-Prot
      Q8R510, Q99NF5, Q9ER64
      Related
      ENSMUSP00000113362.2, ENSMUST00000119499.8
      Conserved Domains (3) summary
      cd13286
      Location:120 → 248
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:127 → 243
      PH; PH domain
      pfam01237
      Location:373 → 706
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001384163.1 → NP_001371092.1  oxysterol-binding protein-related protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which encodes a shorter protein compared to isoform 1.
      Source sequence(s)
      AC068006, AC158299
      Conserved Domains (2) summary
      cd13286
      Location:132 → 260
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:385 → 721
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_024289.2 → NP_077251.1  oxysterol-binding protein-related protein 5 isoform 1

      See identical proteins and their annotated locations for NP_077251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC068006, AC158299
      Consensus CDS
      CCDS40200.1
      UniProtKB/TrEMBL
      G5E833
      Related
      ENSMUSP00000020411.8, ENSMUST00000020411.14
      Conserved Domains (3) summary
      cd13286
      Location:144 → 272
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:151 → 267
      PH; PH domain
      pfam01237
      Location:397 → 730
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143242499..143310745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508659.4 → XP_006508722.1  oxysterol-binding protein-related protein 5 isoform X2

      Conserved Domains (2) summary
      cd13286
      Location:72 → 200
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:325 → 661
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_011242024.1 → XP_011240326.1  oxysterol-binding protein-related protein 5 isoform X1

      Conserved Domains (2) summary
      cd13286
      Location:120 → 248
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:373 → 676
      Oxysterol_BP; Oxysterol-binding protein

    RNA

    1. XR_001778018.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER64.3 GenPept UniProtKB/Swiss-Prot:Q9ER64

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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