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    Serpinb1b serine (or cysteine) peptidase inhibitor, clade B, member 1b [ Mus musculus (house mouse) ]

    Gene ID: 282663, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Serpinb1bprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 1bprovided by MGI
    Primary source
    MGI:MGI:2445361
    See related
    Ensembl:ENSMUSG00000051029 AllianceGenome:MGI:2445361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EIB; Serpin1b1; ovalbumin; 6330533H24Rik
    Summary
    Contributes to serine-type endopeptidase inhibitor activity. Involved in negative regulation of interleukin-1 beta production. Acts upstream of or within regulation of protein catabolic process. Predicted to be located in cytoplasmic ribonucleoprotein granule and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; dorsal grey horn; naris; and physiological umbilical hernia dermis. Orthologous to human SERPINB1 (serpin family B member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 1.7), CNS E14 (RPKM 0.8) and 7 other tissues See more
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    Genomic context

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    See Serpinb1b in Genome Data Viewer
    Location:
    13 A3.3; 13 13.81 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33262478..33278363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33078504..33094380)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9b Neighboring gene predicted gene, 36099 Neighboring gene STARR-seq mESC enhancer starr_34110 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34111 Neighboring gene STARR-seq mESC enhancer starr_34115 Neighboring gene STARR-seq mESC enhancer starr_34116 Neighboring gene prohibitin pseudogene Neighboring gene craniofacial development protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SERPINB1-mediated checkpoint of inflammatory caspase activation. Choi YJ, et al. Nat Immunol, 2019 Mar. PMID 30692621, Free PMC Article
    2. Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product. Bleul CC, et al. Eur J Immunol, 2001 Aug. PMID 11500834
    3. Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). Benarafa C, et al. J Biol Chem, 2002 Nov 1. PMID 12189154
    4. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365
    5. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cDNA cloning, gene structure and biological characterization homologous to human MNEI
      Title: Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte elastase inhibitor B
    Names
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1b
    serine protease inhibitor EIB
    serpin B1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173052.2 → NP_766640.1  leukocyte elastase inhibitor B

      See identical proteins and their annotated locations for NP_766640.1

      Status: VALIDATED

      Source sequence(s)
      BC030354, BE980791, BY109795
      Consensus CDS
      CCDS26433.1
      UniProtKB/Swiss-Prot
      Q8VHP7
      Related
      ENSMUSP00000016951.8, ENSMUST00000016951.8
      Conserved Domains (1) summary
      cd19560
      Location:1 → 382
      serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      33262478..33278363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516684.2 → XP_006516747.1  leukocyte elastase inhibitor B isoform X1

      See identical proteins and their annotated locations for XP_006516747.1

      UniProtKB/Swiss-Prot
      Q8VHP7
      Conserved Domains (1) summary
      cd19560
      Location:1 → 382
      serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

    2. XM_006516686.2 → XP_006516749.1  leukocyte elastase inhibitor B isoform X3

      Conserved Domains (1) summary
      cd19560
      Location:1 → 329
      serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

    3. XM_006516685.3 → XP_006516748.1  leukocyte elastase inhibitor B isoform X2

      Conserved Domains (1) summary
      cd19560
      Location:18 → 344
      serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHP7.1 GenPept UniProtKB/Swiss-Prot:Q8VHP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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