Serpina3i serine (or cysteine) peptidase inhibitor, clade A, member 3I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpina3iprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 3Iprovided by MGI
Primary source: MGI:MGI:2182841
See related: Ensembl:ENSMUSG00000079014 AllianceGenome:MGI:2182841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2B2; Gm6930; EG628900
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 2.5), spleen adult (RPKM 1.1) and 9 other tissues See more
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Genomic context

Location:: 12 E; 12 53.78 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (104229304..104235768)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (104263045..104269509)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to cytokine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine (or cysteine) peptidase inhibitor, clade A, member 3I

Names: alpha-1 antiproteinase; antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 3I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199940.1 → NP_001186869.1 serine (or cysteine) peptidase inhibitor, clade A, member 3I

Status: VALIDATED

Source sequence(s)

AC142112, BY136799, CJ239048

Consensus CDS

CCDS49157.1

UniProtKB/TrEMBL

A2RTV1, D3Z450

Related

ENSMUSP00000105584.3, ENSMUST00000109958.3

Conserved Domains (1) summary

smart00093
Location:46 → 407

SERPIN; SERine Proteinase INhibitors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

104229304..104235768

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315152.1 → XP_017170641.1 serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X1

UniProtKB/TrEMBL

A2RTV1

Conserved Domains (1) summary

cd19551
Location:62 → 457

serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin
XM_006516132.3 → XP_006516195.1 serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X2

UniProtKB/TrEMBL

A2RTV1

Conserved Domains (1) summary

cd19551
Location:62 → 456

serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin
XM_017315153.1 → XP_017170642.1 serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X3

UniProtKB/TrEMBL

A2RTV1

Conserved Domains (1) summary

cd19551
Location:62 → 443

serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin
XM_036157556.1 → XP_036013449.1 serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X5

Conserved Domains (1) summary

cl38926
Location:62 → 237

serpin; SERine Proteinase INhibitors (serpin) family
XM_017315154.1 → XP_017170643.1 serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X4

Conserved Domains (1) summary

cl38926
Location:62 → 238

serpin; SERine Proteinase INhibitors (serpin) family