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    Cox6b2 cytochrome c oxidase subunit 6B2 [ Mus musculus (house mouse) ]

    Gene ID: 333182, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cox6b2provided by MGI
    Official Full Name
    cytochrome c oxidase subunit 6B2provided by MGI
    Primary source
    MGI:MGI:3044182
    See related
    Ensembl:ENSMUSG00000051811 AllianceGenome:MGI:3044182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    COXVIB2; 1700067P11Rik
    Summary
    Located in mitochondrion. Is expressed in genitourinary system; nervous system; and respiratory system. Orthologous to human COX6B2 (cytochrome c oxidase subunit 6B2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 381.6), liver E14.5 (RPKM 28.1) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Cox6b2 in Genome Data Viewer
    Location:
    7 A1; 7 2.75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4754791..4756093, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4751792..4753094, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E127 Neighboring gene predicted gene, 42369 Neighboring gene lysine methyltransferase 5C Neighboring gene STARR-seq mESC enhancer starr_17937 Neighboring gene golgi associated RAB2 interactor family member 5B Neighboring gene interleukin 11 Neighboring gene transmembrane protein 190

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tipping the balance toward stemness in trophoblast: Metabolic programming by Cox6B2. Saha S, et al. FASEB J, 2022 Nov. PMID 36250984
    2. Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c? Hüttemann M, et al. Mol Reprod Dev, 2003 Sep. PMID 12874793
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility.
      Title: Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130249, MGC130250

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial crista IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 6B2
    Names
    cytochrome c oxidase subunit VIb polypeptide 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289848.1 → NP_001276777.1  cytochrome c oxidase subunit 6B2 isoform 1

      See identical proteins and their annotated locations for NP_001276777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (1). Variants 1 through 3 encode the same isoform (1).
      Source sequence(s)
      AW123567, AY152400, BC145201
      Consensus CDS
      CCDS39738.1
      UniProtKB/Swiss-Prot
      Q3KNG2, Q80ZN9
      UniProtKB/TrEMBL
      Q059Q8, V9GWZ7
      Related
      ENSMUSP00000138765.2, ENSMUST00000182048.2
      Conserved Domains (1) summary
      cd00926
      Location:15 → 87
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_001289849.1 → NP_001276778.1  cytochrome c oxidase subunit 6B2 isoform 2

      See identical proteins and their annotated locations for NP_001276778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, resulting in a frameshift and an alternate stop codon, compared to variant 3. It encodes isoform 2, which is similar in size, but has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AW123567, AY152400, BG080371
      Consensus CDS
      CCDS80657.1
      UniProtKB/TrEMBL
      S4R2Q6
      Related
      ENSMUSP00000138744.2, ENSMUST00000182738.8
      Conserved Domains (1) summary
      cl02794
      Location:15 → 57
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    3. NM_001289850.1 → NP_001276779.1  cytochrome c oxidase subunit 6B2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 3. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AW123567, AY152400, BC145201
      Consensus CDS
      CCDS80658.1
      UniProtKB/TrEMBL
      V9GXN3
      Related
      ENSMUSP00000139239.2, ENSMUST00000184143.8
      Conserved Domains (1) summary
      cl02794
      Location:15 → 48
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    4. NM_183405.2 → NP_899664.1  cytochrome c oxidase subunit 6B2 isoform 1

      See identical proteins and their annotated locations for NP_899664.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1 through 3 encode the same isoform (1).
      Source sequence(s)
      AK160152, AW123567, AY152400
      Consensus CDS
      CCDS39738.1
      UniProtKB/Swiss-Prot
      Q3KNG2, Q80ZN9
      UniProtKB/TrEMBL
      Q059Q8, V9GWZ7
      Related
      ENSMUSP00000064988.7, ENSMUST00000063324.14
      Conserved Domains (1) summary
      cd00926
      Location:15 → 87
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    5. NM_183406.3 → NP_899665.1  cytochrome c oxidase subunit 6B2 isoform 1

      See identical proteins and their annotated locations for NP_899665.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1 through 3 encode the same isoform (1).
      Source sequence(s)
      AW123567, BC145201, CT010366, W88135
      Consensus CDS
      CCDS39738.1
      UniProtKB/Swiss-Prot
      Q3KNG2, Q80ZN9
      UniProtKB/TrEMBL
      Q059Q8, V9GWZ7
      Related
      ENSMUSP00000138709.2, ENSMUST00000182111.8
      Conserved Domains (1) summary
      cd00926
      Location:15 → 87
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    RNA

    1. NR_110411.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses alternate splice sites in two internal exons, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC161197, AW123567, AY152400, BC145201
      Related
      ENSMUST00000183334.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4754791..4756093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZN9.1 GenPept UniProtKB/Swiss-Prot:Q80ZN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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