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    Spice1 spindle and centriole associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 212514, updated on 12-May-2024

    Summary

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    Official Symbol
    Spice1provided by MGI
    Official Full Name
    spindle and centriole associated protein 1provided by MGI
    Primary source
    MGI:MGI:1196252
    See related
    Ensembl:ENSMUSG00000043065 AllianceGenome:MGI:1196252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc52; D16Ertd480e
    Summary
    Predicted to be involved in metaphase plate congression; mitotic spindle assembly; and regulation of centriole replication. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centriole; centrosome; and spindle. Is expressed in adenohypophysis; brain ventricular layer; nasal cavity epithelium; testis; and thymus primordium. Orthologous to human SPICE1 (spindle and centriole associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.1), CNS E11.5 (RPKM 5.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spice1 in Genome Data Viewer
    Location:
    16 B4; 16 28.67 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44167761..44208857)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44347399..44388492)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene upstream transcription factor family member 3 Neighboring gene SID1 transmembrane family, member 1 Neighboring gene STARR-seq mESC enhancer starr_40897 Neighboring gene STARR-seq mESC enhancer starr_40898 Neighboring gene STARR-seq mESC enhancer starr_40899 Neighboring gene STARR-seq mESC enhancer starr_40902 Neighboring gene cilia and flagella associated protein 44 Neighboring gene STARR-seq mESC enhancer starr_40903 Neighboring gene STARR-seq mESC enhancer starr_40904 Neighboring gene Boc Hedgehog-responsive enhancer Neighboring gene STARR-seq mESC enhancer starr_40905 Neighboring gene VISTA enhancer mm1504 Neighboring gene BOC cell adhesion associated, oncogene regulated Neighboring gene predicted gene, 30064

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
    2. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spindle and centriole-associated protein 1
    Names
    coiled-coil domain containing 52
    coiled-coil domain-containing protein 52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416915.1 → NP_001403844.1  spindle and centriole-associated protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125191, AC147045
      UniProtKB/Swiss-Prot
      Q8C804, Q8K3I7

    2. NM_001416916.1 → NP_001403845.1  spindle and centriole-associated protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125191, AC147045
      UniProtKB/Swiss-Prot
      Q8C804, Q8K3I7

    3. NM_001416917.1 → NP_001403846.1  spindle and centriole-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125191, AC147045

    4. NM_144550.5 → NP_653133.3  spindle and centriole-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_653133.3

      Status: VALIDATED

      Source sequence(s)
      AC125191, AC147045
      Consensus CDS
      CCDS37345.1
      UniProtKB/Swiss-Prot
      Q8C804, Q8K3I7
      Related
      ENSMUSP00000058832.7, ENSMUST00000050897.7
      Conserved Domains (1) summary
      pfam15678
      Location:35 → 436
      SPICE; Centriole duplication and mitotic chromosome congression

    RNA

    1. NR_184401.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125191, AC147045

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      44167761..44208857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249036.2 → XP_030104896.1  spindle and centriole-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam15678
      Location:1 → 383
      SPICE; Centriole duplication and mitotic chromosome congression

    RNA

    1. XR_004939178.1 RNA Sequence

    2. XR_004939177.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C804.2 GenPept UniProtKB/Swiss-Prot:Q8C804

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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