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    Adarb2 adenosine deaminase, RNA-specific, B2 [ Mus musculus (house mouse) ]

    Gene ID: 94191, updated on 12-May-2024

    Summary

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    Official Symbol
    Adarb2provided by MGI
    Official Full Name
    adenosine deaminase, RNA-specific, B2provided by MGI
    Primary source
    MGI:MGI:2151118
    See related
    Ensembl:ENSMUSG00000052551 AllianceGenome:MGI:2151118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RED2; Adar3
    Summary
    Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; integumental system; limb; and sensory organ. Orthologous to human ADARB2 (adenosine deaminase RNA specific B2 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 3.3), CNS E18 (RPKM 2.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adarb2 in Genome Data Viewer
    Location:
    13 A1; 13 3.48 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (8252475..8818798)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (8202526..8768762)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33590 Neighboring gene STARR-seq mESC enhancer starr_33591 Neighboring gene polo-like kinase 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33592 Neighboring gene STARR-seq mESC enhancer starr_33593 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33594 Neighboring gene STARR-seq mESC enhancer starr_33595 Neighboring gene STARR-seq mESC enhancer starr_33596 Neighboring gene STARR-seq mESC enhancer starr_33598 Neighboring gene STARR-positive B cell enhancer ABC_E8888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:8870257-8870604 Neighboring gene WD repeat domain 37 Neighboring gene isopentenyl-diphosphate delta isomerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADAR3 alleviated inflammation and pyroptosis of neuropathic pain by targeting NLRP3 in chronic constriction injury mice. Li Z, et al. Gene, 2021 Dec 30. PMID 34419568
    2. Adar3 Is Involved in Learning and Memory in Mice. Mladenova D, et al. Front Neurosci, 2018. PMID 29719497, Free PMC Article
    3. Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes from mammals, pufferfish and zebrafish. Slavov D, et al. Gene, 2000 May 30. PMID 10854777
    4. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nicod J, et al. Nat Genet, 2016 Aug. PMID 27376238, Free PMC Article
    5. Reprogramming of microRNAs by adenosine-to-inosine editing and the selective elimination of edited microRNA precursors in mouse oocytes and preimplantation embryos. García-López J, et al. Nucleic Acids Res, 2013 May 1. PMID 23571754, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAR3 alleviated inflammation and pyroptosis of neuropathic pain by targeting NLRP3 in chronic constriction injury mice.
      Title: ADAR3 alleviated inflammation and pyroptosis of neuropathic pain by targeting NLRP3 in chronic constriction injury mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    double-stranded RNA-specific editase B2
    Names
    RNA dependent adenosine deaminase 3
    RNA-editing deaminase 2
    RNA-editing enzyme 2
    adenosine deaminase 3, RNA dependent
    dsRNA adenosine deaminase B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289530.1 → NP_001276459.1  double-stranded RNA-specific editase B2 isoform 2

      See identical proteins and their annotated locations for NP_001276459.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, which results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK046083, AK134964
      Consensus CDS
      CCDS70428.1
      UniProtKB/TrEMBL
      Q6PB89, Q8BQZ3
      Related
      ENSMUSP00000120757.2, ENSMUST00000123187.2
      Conserved Domains (2) summary
      smart00552
      Location:366 → 687
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:125 → 189
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    2. NM_052977.5 → NP_443209.2  double-stranded RNA-specific editase B2 isoform 1

      See identical proteins and their annotated locations for NP_443209.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK134964, AK139079
      Consensus CDS
      CCDS26231.1
      UniProtKB/Swiss-Prot
      Q3UTP1, Q8CC51, Q9JI20, Q9JIE5
      UniProtKB/TrEMBL
      Q3UY54
      Related
      ENSMUSP00000064775.7, ENSMUST00000064473.13
      Conserved Domains (3) summary
      smart00358
      Location:284 → 331
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:366 → 742
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:125 → 189
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    RNA

    1. NR_110345.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and has a novel 3' terminus, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK134964, AV327940, BC059822

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      8252475..8818798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315647.3 → XP_017171136.1  double-stranded RNA-specific editase B2 isoform X1

      UniProtKB/TrEMBL
      Q3UY54
      Conserved Domains (3) summary
      smart00552
      Location:366 → 739
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19896
      Location:122 → 195
      DSRM_RED2_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 2 (RED2) and similar proteins
      cl00054
      Location:276 → 349
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    RNA

    1. XR_382016.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JI20.2 GenPept UniProtKB/Swiss-Prot:Q9JI20

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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