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    Nol4 nucleolar protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 319211, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Nol4provided by MGI
    Official Full Name
    nucleolar protein 4provided by MGI
    Primary source
    MGI:MGI:2441684
    See related
    Ensembl:ENSMUSG00000041923 AllianceGenome:MGI:2441684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1262; 1700013J13Rik; 4930568N03Rik
    Summary
    Predicted to be located in nucleolus. Is expressed in brain; neural retina; olfactory epithelium; and spinal cord. Orthologous to human NOL4 (nucleolar protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 10.4), CNS E18 (RPKM 10.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nol4 in Genome Data Viewer
    Location:
    18 A2; 18 11.96 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (22826209..23174926, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (22693152..23042640, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41676 Neighboring gene STARR-seq mESC enhancer starr_44026 Neighboring gene STARR-seq mESC enhancer starr_44028 Neighboring gene ASXL transcriptional regulator 3 Neighboring gene STARR-seq mESC enhancer starr_44029 Neighboring gene STARR-seq mESC enhancer starr_44030 Neighboring gene STARR-seq mESC enhancer starr_44031 Neighboring gene STARR-seq mESC enhancer starr_44032 Neighboring gene STARR-seq mESC enhancer starr_44033 Neighboring gene STARR-seq mESC enhancer starr_44034 Neighboring gene STARR-seq mESC enhancer starr_44036 Neighboring gene predicted gene, 22495 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comprehensive Transcriptomic Profiling of Murine Osteoclast Differentiation Reveals Novel Differentially Expressed Genes and LncRNAs. Toor SM, et al. Front Genet, 2021. PMID 34868271, Free PMC Article
    2. Splicing variants of NOL4 differentially regulate the transcription activity of Mlr1 and Mlr2 in cultured cells. Takayanagi-Kiya S, et al. Zoolog Sci, 2014 Nov. PMID 25366156
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161483.1 → NP_001154955.1  nucleolar protein 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate 5' terminal exon, resulting in a different 5' UTR and the use of an alternate start codon, compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 3.
      Source sequence(s)
      AK029800, BB263751, BB578752, BC056377
      Consensus CDS
      CCDS50235.1
      UniProtKB/Swiss-Prot
      P60954
      UniProtKB/TrEMBL
      Q8C0U4
      Related
      ENSMUSP00000080150.7, ENSMUST00000081423.13

    2. NM_001347509.1 → NP_001334438.1  nucleolar protein 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AC102361, AC103368, AC131338
      Consensus CDS
      CCDS84363.1
      UniProtKB/TrEMBL
      E9Q947
      Related
      ENSMUSP00000130950.2, ENSMUST00000164186.8

    3. NM_001347510.1 → NP_001334439.1  nucleolar protein 4 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region compared to variant 3. The encoded isoform (4) is shorter than isoform 3.
      Source sequence(s)
      AC102361, AC103368, AC131338
      Consensus CDS
      CCDS84362.1
      UniProtKB/TrEMBL
      G3UW35
      Related
      ENSMUSP00000127870.2, ENSMUST00000164893.8

    4. NM_001361223.1 → NP_001348152.1  nucleolar protein 4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 3. The resulting isoform (5) has a shorter N-terminus, compared to isoform 3.
      Source sequence(s)
      AC102361, AC103368, AC131338

    5. NM_001361224.1 → NP_001348153.1  nucleolar protein 4 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 3. The resulting isoform (6) has a shorter N-terminus, compared to isoform 3.
      Source sequence(s)
      AC102361, AC103368, AC131338

    6. NM_001361225.1 → NP_001348154.1  nucleolar protein 4 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 3. The resulting isoform (6) has a shorter N-terminus, compared to isoform 3.
      Source sequence(s)
      AC102361, AC103368, AC131338

    7. NM_199024.3 → NP_950189.2  nucleolar protein 4 isoform 2

      See identical proteins and their annotated locations for NP_950189.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, and uses an alternate splice site in the 3' coding region that causes a frameshift, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 3.
      Source sequence(s)
      AC102361, AC103368, AC131338
      Consensus CDS
      CCDS29093.2
      UniProtKB/Swiss-Prot
      P60954
      Related
      ENSMUSP00000095256.4, ENSMUST00000097651.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      22826209..23174926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250501.2 → XP_030106361.1  nucleolar protein 4 isoform X3

    2. XM_036161167.1 → XP_036017060.1  nucleolar protein 4 isoform X6

      Conserved Domains (1) summary
      NF033845
      Location:229 → 398
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    3. XM_030250502.2 → XP_030106362.1  nucleolar protein 4 isoform X3

    4. XM_006525999.4 → XP_006526062.1  nucleolar protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006526062.1

      UniProtKB/Swiss-Prot
      P60954
      Conserved Domains (1) summary
      pfam17921
      Location:15 → 50
      Integrase_H2C2; Integrase zinc binding domain

    5. XM_030250504.2 → XP_030106364.1  nucleolar protein 4 isoform X5

    6. XM_030250503.2 → XP_030106363.1  nucleolar protein 4 isoform X4

      Conserved Domains (1) summary
      pfam17921
      Location:15 → 50
      Integrase_H2C2; Integrase zinc binding domain

    7. XM_030250499.2 → XP_030106359.1  nucleolar protein 4 isoform X2

      Conserved Domains (1) summary
      pfam17921
      Location:37 → 91
      Integrase_H2C2; Integrase zinc binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60954.2 GenPept UniProtKB/Swiss-Prot:P60954

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