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    Rab42 RAB42, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 242681, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rab42provided by MGI
    Official Full Name
    RAB42, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:2441753
    See related
    Ensembl:ENSMUSG00000089687 AllianceGenome:MGI:2441753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab42-ps; 9530096D07Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in pons mantle layer and rest of cerebellum mantle layer. Orthologous to human RAB42 (RAB42, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 4.0), genital fat pad adult (RPKM 3.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab42 in Genome Data Viewer
    Location:
    4 D2.3; 4 65.14 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132027749..132030693, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132300438..132303382, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene U11 small nuclear RNA Neighboring gene STARR-positive B cell enhancer ABC_E3519 Neighboring gene TATA-box binding protein associated factor 12 Neighboring gene STARR-positive B cell enhancer ABC_E6228 Neighboring gene STARR-positive B cell enhancer ABC_E7994 Neighboring gene small nucleolar RNA, H/ACA box 16A Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, H/ACA box 44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes. Marubashi S, et al. Cell Struct Funct, 2020 Mar 18. PMID 32037382, Free PMC Article
    2. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727
    3. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082
    4. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12578829
    5. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes.
      Title: Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-42
    Names
    RAB42, member RAS oncogene family, pseudogene
    putative Ras-related protein Rab-42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081651.1 → NP_001075120.1  ras-related protein Rab-42

      See identical proteins and their annotated locations for NP_001075120.1

      Status: VALIDATED

      Source sequence(s)
      AL670276
      Consensus CDS
      CCDS38898.1
      UniProtKB/Swiss-Prot
      Q0PD08
      Related
      ENSMUSP00000047735.7, ENSMUST00000040411.7
      Conserved Domains (1) summary
      cl21455
      Location:8 → 215
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132027749..132030693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538847.2 → XP_006538910.1  ras-related protein Rab-42 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:8 → 219
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0PD08.1 GenPept UniProtKB/Swiss-Prot:Q0PD08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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