Cd3g CD3 antigen, gamma polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd3gprovided by MGI
Official Full Name: CD3 antigen, gamma polypeptideprovided by MGI
Primary source: MGI:MGI:88333
See related: Ensembl:ENSMUSG00000002033 AllianceGenome:MGI:88333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T3g; Ctg3; Ctg-3
Summary: Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including positive thymic T cell selection; protein transport; and regulation of lymphocyte apoptotic process. Predicted to act upstream of or within adaptive immune response. Part of alpha-beta T cell receptor complex. Human ortholog(s) of this gene implicated in immunodeficiency 17. Orthologous to human CD3G (CD3g molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 54.5), spleen adult (RPKM 5.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44880870..44891729, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44969572..44980431, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
Title: Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
CD3gammaepsilon dimers predominated over CD3deltaepsilon dimers at the early stage of T cell development.
Title: Dynamics of CD3gammaepsilon and CD3deltaepsilon dimer expression during murine T cell development.
Our study thus identifies an important role of CD3gamma-mediated TCR down-regulation in T cell homeostasis.
Title: TCR down-regulation controls T cell homeostasis.
CD3delta transgene rescues gammadelta T cell development in mice lacking both mouse CD3delta and CD3gamma.
Title: Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies.
These animals had also a lower number of apoptotic graft infiltrating T cells, whereas the expression of intracellular interferon-gamma in CD3CD4 T cells was increased.
Title: ICOS/B7RP-1 interference in mouse kidney transplantation.
CD3delta and CD3gamma play a different role in humans and mice in pre-TCR and TCR function during alphabeta T-cell development
Title: Overlapping functions of human CD3delta and mouse CD3gamma in alphabeta T-cell development revealed in a humanized CD3gamma-mouse.
A human CD3 transgene that encodes full length CD3delta and a truncated but functional form of CD3epsilon restored the defective preTCR function in not only CD3epsilon- but CD3gamma- and CD3gammadelta-deficient mice as well.
Title: Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y00635 (e-PCR)
- UniSTS:125908

D9Mit255 (e-PCR), detects polymorphism
- UniSTS:131825

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in positive thymic T cell selection	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of lymphocyte apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of alpha-beta T cell receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of alpha-beta T cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of alpha-beta T cell receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-cell surface glycoprotein CD3 gamma chain

Names: T-cell receptor T3 gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009850.2 → NP_033980.1 T-cell surface glycoprotein CD3 gamma chain precursor

See identical proteins and their annotated locations for NP_033980.1

Status: VALIDATED

Source sequence(s)

AC061963, BC027528, BY224047

Consensus CDS

CCDS23123.1

UniProtKB/Swiss-Prot

P11942

UniProtKB/TrEMBL

Q3U4Y3, Q3UZ65

Related

ENSMUSP00000002101.6, ENSMUST00000002101.12

Conserved Domains (2) summary

pfam02189
Location:157 → 176

ITAM; Immunoreceptor tyrosine-based activation motif

pfam16680
Location:40 → 106

Ig_4; T-cell surface glycoprotein CD3 delta chain