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    Ascc2 activating signal cointegrator 1 complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 75452, updated on 12-May-2024

    Summary

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    Official Symbol
    Ascc2provided by MGI
    Official Full Name
    activating signal cointegrator 1 complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1922702
    See related
    Ensembl:ENSMUSG00000020412 AllianceGenome:MGI:1922702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ASC1p100; 1700011I11Rik; 2610034L15Rik
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in regulation of transcription, DNA-templated; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of activating signal cointegrator 1 complex. Is expressed in several structures, including adrenal gland; alimentary system; aorta; brain; and genitourinary system. Orthologous to human ASCC2 (activating signal cointegrator 1 complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.3), bladder adult (RPKM 12.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ascc2 in Genome Data Viewer
    Location:
    11 A1; 11 2.94 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4587698..4635699)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4637696..4685699)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E728 Neighboring gene STARR-positive B cell enhancer ABC_E3930 Neighboring gene predicted gene 11961 Neighboring gene STARR-seq mESC enhancer starr_28397 Neighboring gene STARR-seq mESC enhancer starr_28398 Neighboring gene STARR-positive B cell enhancer ABC_E2979 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit X Neighboring gene zinc finger, matrin type 5 Neighboring gene STARR-seq mESC enhancer starr_28401 Neighboring gene calcium binding protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure With Preserved Ejection Fraction. Cao Y, et al. Circulation, 2022 Apr 5. PMID 35377742, Free PMC Article
    2. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Lee J, et al. Proc Natl Acad Sci U S A, 2008 Dec 9. PMID 19047629, Free PMC Article
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ASC-2, MLL3, and MLL4 are recruited to the PPARgamma-activated aP2 gene during adipogenesis
      Title: Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21588

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA repair complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of activating signal cointegrator 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    activating signal cointegrator 1 complex subunit 2
    Names
    ASC-1 complex subunit P100
    trip4 complex subunit p100

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376980.1 → NP_001363909.1  activating signal cointegrator 1 complex subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606521
      UniProtKB/TrEMBL
      Q3UG63
      Conserved Domains (1) summary
      cd14364
      Location:353 → 392
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    2. NM_029291.2 → NP_083567.1  activating signal cointegrator 1 complex subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_083567.1

      Status: VALIDATED

      Source sequence(s)
      AL606521
      Consensus CDS
      CCDS24387.1
      UniProtKB/Swiss-Prot
      Q5NCK1, Q8BKM9, Q8BX60, Q8R1B9, Q91WR3
      UniProtKB/TrEMBL
      Q3UG63
      Related
      ENSMUSP00000063272.8, ENSMUST00000070257.14
      Conserved Domains (1) summary
      cd14364
      Location:467 → 506
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4587698..4635699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_380985.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WR3.1 GenPept UniProtKB/Swiss-Prot:Q91WR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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