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    Nemp1 nuclear envelope integral membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 210035, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Nemp1provided by MGI
    Official Full Name
    nuclear envelope integral membrane protein 1provided by MGI
    Primary source
    MGI:MGI:2446113
    See related
    Ensembl:ENSMUSG00000040195 AllianceGenome:MGI:2446113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem194; Tmem194a
    Summary
    Predicted to be involved in nuclear membrane organization. Located in nuclear envelope. Orthologous to human NEMP1 (nuclear envelope integral membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 9.0), liver E14 (RPKM 1.3) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nemp1 in Genome Data Viewer
    Location:
    10 D3; 10 74.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127512934..127536918)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127677065..127701049)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012D01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127105871-127106058 Neighboring gene STARR-positive B cell enhancer ABC_E2971 Neighboring gene STARR-positive B cell enhancer ABC_E1133 Neighboring gene predicted gene 16230 Neighboring gene STARR-positive B cell enhancer ABC_E5197 Neighboring gene myosin IA Neighboring gene tachykinin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. Hodzic D, et al. PLoS Biol, 2022 Oct. PMID 36215313, Free PMC Article
    2. The NEMP family supports metazoan fertility and nuclear envelope stiffness. Tsatskis Y, et al. Sci Adv, 2020 Aug. PMID 32923640, Free PMC Article
    3. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. Shibano T, et al. PLoS One, 2015. PMID 25946333, Free PMC Article
    4. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts.
      Title: The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts.
    2. Nemp1 represents a new type of RanGTP-binding protein.
      Title: The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40914

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in erythrocyte enucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in erythrocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear envelope integral membrane protein 1
    Names
    transmembrane protein 194
    transmembrane protein 194A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113211.1 → NP_001106682.1  nuclear envelope integral membrane protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001106682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC160970, AK129110
      Consensus CDS
      CCDS48720.1
      UniProtKB/Swiss-Prot
      Q6ZQE4
      UniProtKB/TrEMBL
      E9Q6Z3
      Related
      ENSMUSP00000045988.5, ENSMUST00000048099.5
      Conserved Domains (1) summary
      pfam10225
      Location:150 → 396
      NEMP; NEMP family

    2. NM_173732.3 → NP_776093.1  nuclear envelope integral membrane protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_776093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) has a distinct and shorter C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC160970, AK090031
      Consensus CDS
      CCDS48721.1
      UniProtKB/TrEMBL
      Q8K2N3
      Related
      ENSMUSP00000113337.2, ENSMUST00000118612.8
      Conserved Domains (1) summary
      pfam10225
      Location:150 → 321
      DUF2215; Uncharacterized conserved protein (DUF2215)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127512934..127536918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243393.2 → XP_011241695.1  nuclear envelope integral membrane protein 1 isoform X1

      Conserved Domains (1) summary
      pfam10225
      Location:1 → 207
      NEMP; NEMP family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQE4.2 GenPept UniProtKB/Swiss-Prot:Q6ZQE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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