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    Maip1 matrix AAA peptidase interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 68115, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Maip1provided by MGI
    Official Full Name
    matrix AAA peptidase interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1915365
    See related
    Ensembl:ENSMUSG00000025971 AllianceGenome:MGI:1915365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9430016H08Rik
    Summary
    Predicted to enable ribosome binding activity. Predicted to be involved in calcium import into the mitochondrion; mitochondrial calcium ion homeostasis; and mitochondrial membrane organization. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrial inner membrane. Orthologous to human MAIP1 (matrix AAA peptidase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 13.0), placenta adult (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Maip1 in Genome Data Viewer
    Location:
    1 C1.3; 1 28.79 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (57445425..57457112)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57406266..57417953)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930558J18 gene Neighboring gene RIKEN cDNA 1700066M21 gene Neighboring gene STARR-seq mESC enhancer starr_00984 Neighboring gene tRNA-yW synthesizing protein 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:57463249-57463358 Neighboring gene predicted gene, 22371 Neighboring gene predicted gene, 53555 Neighboring gene STARR-seq mESC enhancer starr_00987

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Chai G, et al. Neuron, 2021 Jan 20. PMID 33220177, Free PMC Article
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane from matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    m-AAA protease-interacting protein 1, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081181.3 → NP_001074650.1  m-AAA protease-interacting protein 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001074650.1

      Status: VALIDATED

      Source sequence(s)
      AC161493, AK079116
      Consensus CDS
      CCDS48266.1
      UniProtKB/Swiss-Prot
      Q8BHE8, Q8R3N9
      Related
      ENSMUSP00000027114.6, ENSMUST00000027114.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      57445425..57457112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026564.1: Suppressed sequence

      Description
      NM_026564.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHE8.1 GenPept UniProtKB/Swiss-Prot:Q8BHE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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