Serpinb6e serine (or cysteine) peptidase inhibitor, clade B, member 6e [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb6eprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B, member 6eprovided by MGI
Primary source: MGI:MGI:2667778
See related: Ensembl:ENSMUSG00000069248 AllianceGenome:MGI:2667778
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SPI3B; Gm11396; ovalbumin
Summary: Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Predicted to be part of serine protease inhibitor complex. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 13 A3.3; 13 13.98 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (34016328..34027391, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (33832345..33843408, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Serpinb6e (e-PCR), detects polymorphism
- UniSTS:531236

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protease binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of serine protease inhibitor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine (or cysteine) peptidase inhibitor, clade B, member 6e

Names: novel serine (or cysteine) proteinase inhibitor, clade B (Serpinb) member; serine (or cysteine) proteinase inhibitor, clade B, member 6e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045535.2 → NP_001039000.2 serine (or cysteine) peptidase inhibitor, clade B, member 6e

See identical proteins and their annotated locations for NP_001039000.2

Status: VALIDATED

Source sequence(s)

AL450406

Consensus CDS

CCDS26440.2

UniProtKB/TrEMBL

I7HJI3

Related

ENSMUSP00000105904.2, ENSMUST00000110275.8

Conserved Domains (1) summary

cl38926
Location:53 → 429

serpin; SERine Proteinase INhibitors (serpin) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

34016328..34027391 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244319.2 → XP_011242621.1 serine (or cysteine) peptidase inhibitor, clade B, member 6e isoform X1

See identical proteins and their annotated locations for XP_011242621.1

UniProtKB/TrEMBL

I7HJI3

Conserved Domains (1) summary

cl38926
Location:53 → 429

serpin; SERine Proteinase INhibitors (serpin) family