Fgd3 FYVE, RhoGEF and PH domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgd3provided by MGI
Official Full Name: FYVE, RhoGEF and PH domain containing 3provided by MGI
Primary source: MGI:MGI:1353657
See related: Ensembl:ENSMUSG00000037946 AllianceGenome:MGI:1353657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZFYVE5; 5830461L01Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Involved in filopodium assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in several structures, including lung; musculature; nervous system; and spleen. Orthologous to human FGD3 (FYVE, RhoGEF and PH domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 7.4), thymus adult (RPKM 4.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 25.18 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (49415030..49473783, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (49261554..49320313, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGD3, which was identified as a homologue of FGD1 but has been poorly characterized, has conserved the same motif and is down-regulated similarly by SCF(FWD1/beta-TrCP).
Title: Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

Fgd3 (e-PCR), detects polymorphism
- UniSTS:164686

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in filopodium assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FYVE, RhoGEF and PH domain-containing protein 3

Names: Fgd1 family, member 3; faciogenital dysplasia homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015759.2 → NP_056574.2 FYVE, RhoGEF and PH domain-containing protein 3

See identical proteins and their annotated locations for NP_056574.2

Status: VALIDATED

Source sequence(s)

AK157835

Consensus CDS

CCDS26499.1

UniProtKB/Swiss-Prot

A2RT26, O88842, Q8BQ72

UniProtKB/TrEMBL

Q3TNB8

Related

ENSMUSP00000105714.3, ENSMUST00000110087.9

Conserved Domains (4) summary

cd00160
Location:156 → 335

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13236
Location:606 → 710

PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus

cd15740
Location:527 → 580

FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

cl17171
Location:367 → 474

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

49415030..49473783 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158066.1 → XP_036013959.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform X2

UniProtKB/Swiss-Prot

A2RT26, O88842, Q8BQ72

Conserved Domains (4) summary

cd00160
Location:156 → 335

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13236
Location:570 → 674

PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus

cd15740
Location:491 → 544

FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

cl17171
Location:367 → 460

PH-like; Pleckstrin homology-like domain
XM_006516929.5 → XP_006516992.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006516992.1

UniProtKB/Swiss-Prot

A2RT26, O88842, Q8BQ72

UniProtKB/TrEMBL

Q3TNB8

Conserved Domains (4) summary

cd00160
Location:156 → 335

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13236
Location:606 → 710

PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus

cd15740
Location:527 → 580

FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

cl17171
Location:367 → 474

PH-like; Pleckstrin homology-like domain
XM_006516930.5 → XP_006516993.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006516993.1

UniProtKB/Swiss-Prot

A2RT26, O88842, Q8BQ72

UniProtKB/TrEMBL

Q3TNB8

Conserved Domains (4) summary

cd00160
Location:156 → 335

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13236
Location:606 → 710

PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus

cd15740
Location:527 → 580

FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

cl17171
Location:367 → 474

PH-like; Pleckstrin homology-like domain
XM_036158065.1 → XP_036013958.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

A2RT26, O88842, Q8BQ72

UniProtKB/TrEMBL

Q3TNB8

Conserved Domains (4) summary

cd00160
Location:156 → 335

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13236
Location:606 → 710

PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus

cd15740
Location:527 → 580

FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

cl17171
Location:367 → 474

PH-like; Pleckstrin homology-like domain
XM_006516931.5 → XP_006516994.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006516994.1

UniProtKB/Swiss-Prot

A2RT26, O88842, Q8BQ72

UniProtKB/TrEMBL

Q3TNB8

Related

ENSMUSP00000048692.5, ENSMUST00000048716.11

Conserved Domains (4) summary

cd00160
Location:156 → 335

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13236
Location:606 → 710

PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus

cd15740
Location:527 → 580

FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

cl17171
Location:367 → 474

PH-like; Pleckstrin homology-like domain