Zkscan14 zinc finger with KRAB and SCAN domains 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zkscan14provided by MGI
Official Full Name: zinc finger with KRAB and SCAN domains 14provided by MGI
Primary source: MGI:MGI:1914485
See related: Ensembl:ENSMUSG00000029627 AllianceGenome:MGI:1914485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp99; Znf394; 2310046C23Rik; 2810437E14Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF394 (zinc finger protein 394). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 2.2), cerebellum adult (RPKM 2.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 85.12 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (145131756..145140972, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (145194946..145204164, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.
Title: ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126711 (e-PCR)
- UniSTS:207914

Zkscan14 (e-PCR), detects polymorphism
- UniSTS:547391

NoName (e-PCR)
- UniSTS:235364

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 394

Names: zfp-94; zinc finger protein 94; zinc finger protein 99; zinc finger protein with KRAB and SCAN domains 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023322.2 → NP_075811.2 zinc finger protein 394

See identical proteins and their annotated locations for NP_075811.2

Status: VALIDATED

Source sequence(s)

AI195146, AK013258, CJ072232

Consensus CDS

CCDS19860.1

UniProtKB/Swiss-Prot

B9EIZ4, Q3U4Z1, Q9CYV9, Q9CZG8, Q9Z1D9

Related

ENSMUSP00000031632.9, ENSMUST00000031632.9

Conserved Domains (8) summary

smart00431
Location:40 → 151

SCAN; leucine rich region

cd07765
Location:135 → 173

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

smart00349
Location:135 → 193

KRAB; krueppel associated box

COG5048
Location:303 → 484

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:329 → 349

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:438 → 460

zf-C2H2; Zinc finger, C2H2 type

pfam02023
Location:40 → 128

SCAN; SCAN domain

pfam13465
Location:341 → 366

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

145131756..145140972 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241012.4 → XP_011239314.1 zinc finger protein 394 isoform X1

Conserved Domains (4) summary

smart00349
Location:1 → 59

KRAB; krueppel associated box

COG5048
Location:169 → 350

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:195 → 215

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:347 → 371

zf-H2C2_2; Zinc-finger double domain