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    Pou5f2 POU domain class 5, transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 75507, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pou5f2provided by MGI
    Official Full Name
    POU domain class 5, transcription factor 2provided by MGI
    Primary source
    MGI:MGI:1922757
    See related
    Ensembl:ENSMUSG00000093668 AllianceGenome:MGI:1922757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sprm1; SPRM-1; 1700013G10Rik
    Summary
    Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system and dorsal root ganglion. Orthologous to human POU5F2 (POU domain class 5, transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    See Pou5f2 in Genome Data Viewer
    Location:
    13 C1; 13 41.38 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (78173021..78174415)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (78024902..78026296)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35071 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11549 Neighboring gene predicted gene, 26088 Neighboring gene STARR-seq mESC enhancer starr_35072 Neighboring gene ARB2 cotranscriptional regulator A Neighboring gene STARR-seq mESC enhancer starr_35073 Neighboring gene STARR-seq mESC enhancer starr_35075 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit A pseudogene Neighboring gene STARR-seq mESC enhancer starr_35076 Neighboring gene RIKEN cDNA 3110006O06 gene Neighboring gene predicted gene, 38604

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced fertility in mice deficient for the POU protein sperm-1. Pearse RV 2nd, et al. Proc Natl Acad Sci U S A, 1997 Jul 8. PMID 9207130, Free PMC Article
    2. The POU-er of gene nomenclature. Frankenberg SR, et al. Development, 2014 Aug. PMID 25053425
    3. Sperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell. Andersen B, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 7902581, Free PMC Article
    4. A mutation in the nuclear pore complex gene Tmem48 causes gametogenesis defects in skeletal fusions with sterility (sks) mice. Akiyama K, et al. J Biol Chem, 2013 Nov 1. PMID 24045954, Free PMC Article
    5. Chromosomal organization of mammalian POU domain factors. Xia YR, et al. Genomics, 1993 Oct. PMID 8276396

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    POU domain, class 5, transcription factor 2
    Names
    sperm 1 POU domain transcription factor
    sperm-associated POU domain protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029315.1 → NP_083591.1  POU domain, class 5, transcription factor 2

      See identical proteins and their annotated locations for NP_083591.1

      Status: VALIDATED

      Source sequence(s)
      AK005948, AK076753
      Consensus CDS
      CCDS56895.1
      UniProtKB/Swiss-Prot
      Q8BVS2, Q9DAC9
      UniProtKB/TrEMBL
      A0A0R4J273
      Related
      ENSMUSP00000135597.2, ENSMUST00000175955.4
      Conserved Domains (2) summary
      pfam00046
      Location:214 → 250
      Homeobox; Homeobox domain
      pfam00157
      Location:113 → 181
      Pou; Pou domain - N-terminal to homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      78173021..78174415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAC9.1 GenPept UniProtKB/Swiss-Prot:Q9DAC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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