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    Pgs1 phosphatidylglycerophosphate synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 74451, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Pgs1provided by MGI
    Official Full Name
    phosphatidylglycerophosphate synthase 1provided by MGI
    Primary source
    MGI:MGI:1921701
    See related
    Ensembl:ENSMUSG00000017715 AllianceGenome:MGI:1921701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SAF; 2610019F11Rik; 4933424M23Rik
    Summary
    Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Predicted to be involved in cardiolipin biosynthetic process. Predicted to act upstream of or within phospholipid biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and skin. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 69.2), lung adult (RPKM 38.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pgs1 in Genome Data Viewer
    Location:
    11 E2; 11 82.96 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117876505..117914837)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117986297..118024011)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5307 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733294-117733546 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733656-117733839 Neighboring gene predicted gene 11725 Neighboring gene threonine aldolase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117774097-117774206 Neighboring gene STARR-seq mESC enhancer starr_31285 Neighboring gene STARR-positive B cell enhancer ABC_E8474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117813554-117813821 Neighboring gene STARR-positive B cell enhancer ABC_E5308 Neighboring gene STARR-seq mESC enhancer starr_31288 Neighboring gene STARR-positive B cell enhancer ABC_E7103 Neighboring gene suppressor of cytokine signaling 3 Neighboring gene STARR-seq mESC enhancer starr_31291 Neighboring gene microRNA 6933 Neighboring gene STARR-positive B cell enhancer ABC_E7104 Neighboring gene STARR-seq mESC enhancer starr_31293 Neighboring gene STARR-seq mESC enhancer starr_31294 Neighboring gene dynein, axonemal, heavy chain 17 Neighboring gene STARR-seq mESC enhancer starr_31295 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117947366-117947549 Neighboring gene STARR-positive B cell enhancer ABC_E1438 Neighboring gene STARR-positive B cell enhancer ABC_E9849 Neighboring gene predicted gene 11738 Neighboring gene predicted gene, 38514

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
    Names
    PGP synthase 1
    silencer-associated factor
    NP_598518.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133757.2 → NP_598518.1  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

      See identical proteins and their annotated locations for NP_598518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer protein-coding transcript.
      Source sequence(s)
      AK049359
      Consensus CDS
      CCDS25698.1
      UniProtKB/Swiss-Prot
      Q8BHF7, Q8QZT9, Q8R4R7
      UniProtKB/TrEMBL
      B9EKS7, F8WI04
      Related
      ENSMUSP00000121973.2, ENSMUST00000132676.8
      Conserved Domains (2) summary
      cd09135
      Location:93 → 266
      PLDc_PGS1_euk_1; Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases
      cd09137
      Location:346 → 505
      PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases

    RNA

    1. NR_151726.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK046174, AK049359, AK163967, AW045732
      Related
      ENSMUST00000017859.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      117876505..117914837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_388542.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHF7.1 GenPept UniProtKB/Swiss-Prot:Q8BHF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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