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    Ccnl2 cyclin L2 [ Mus musculus (house mouse) ]

    Gene ID: 56036, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ccnl2provided by MGI
    Official Full Name
    cyclin L2provided by MGI
    Primary source
    MGI:MGI:1927119
    See related
    Ensembl:ENSMUSG00000029068 AllianceGenome:MGI:1927119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcee; SB138; Ania-6b; HCLA-150; 1700010A01Rik; 1810019L15Rik; 2010319M22Rik
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CCNL2 (cyclin L2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 65.5), bladder adult (RPKM 45.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccnl2 in Genome Data Viewer
    Location:
    4 E2; 4 87.47 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155894468..155909005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155810219..155824543)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12274 Neighboring gene ankyrin repeat domain 65 Neighboring gene mitochondrial ribosomal protein L20 Neighboring gene STARR-positive B cell enhancer ABC_E3560 Neighboring gene STARR-seq mESC enhancer starr_12275 Neighboring gene STARR-positive B cell enhancer ABC_E4740 Neighboring gene STARR-positive B cell enhancer ABC_E8042 Neighboring gene aurora kinase A interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10297 Neighboring gene matrix-remodelling associated 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of proliferation and differentiation and promotion of apoptosis by cyclin L2 in mouse embryonic carcinoma P19 cells. Zhuo L, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19785986
    2. Patterns of gene expression along the crypt-villus axis in mouse jejunal epithelium. Cheng H, et al. Anat Rec, 1996 Jan. PMID 8838426
    3. CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. Chen HH, et al. Biochem Biophys Res Commun, 2007 Mar 16. PMID 17261272
    4. CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis. Rakkaa T, et al. Chromosome Res, 2014 Sep. PMID 24436071
    5. CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway. Yun X, et al. Mol Cell Biochem, 2007 Oct. PMID 17516030

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC21593

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of centrosome cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-L2
    Names
    cyclin Ania-6b
    paneth cell enhanced expression
    paneth cell-enhanced expression protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401306.1 → NP_001388235.1  cyclin-L2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670236

    2. NM_207678.3 → NP_997561.1  cyclin-L2 isoform 1

      See identical proteins and their annotated locations for NP_997561.1

      Status: VALIDATED

      Source sequence(s)
      AL670236
      Consensus CDS
      CCDS19042.1
      UniProtKB/Swiss-Prot
      A2AD95, A2RSY2, Q5XK66, Q60995, Q8C136, Q8CIJ8, Q99L73, Q9JJA7, Q9QXH5
      Related
      ENSMUSP00000030944.5, ENSMUST00000030944.11
      Conserved Domains (2) summary
      smart00385
      Location:198 → 280
      CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
      cd00043
      Location:75 → 151
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155894468..155909005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164254.1 → XP_036020147.1  cyclin-L2 isoform X1

      Conserved Domains (2) summary
      cd20590
      Location:33 → 188
      CYCLIN_CCNL2_rpt1; first cyclin box found in cyclin-2 (CCNL2) and similar proteins
      cd20593
      Location:193 → 315
      CYCLIN_CCNL2_rpt2; second cyclin box found in cyclin-2 (CCNL2) and similar proteins

    2. XM_011250305.4 → XP_011248607.2  cyclin-L2 isoform X2

      Conserved Domains (1) summary
      cl40454
      Location:1 → 95
      CYCLIN_SF; Cyclin box fold superfamily

    3. XM_036164256.1 → XP_036020149.1  cyclin-L2 isoform X3

      Conserved Domains (1) summary
      cl40454
      Location:1 → 95
      CYCLIN_SF; Cyclin box fold superfamily

    4. XM_036164255.1 → XP_036020148.1  cyclin-L2 isoform X2

      Conserved Domains (1) summary
      cl40454
      Location:1 → 95
      CYCLIN_SF; Cyclin box fold superfamily

    5. XM_030253679.2 → XP_030109539.1  cyclin-L2 isoform X3

      Conserved Domains (1) summary
      cl40454
      Location:1 → 95
      CYCLIN_SF; Cyclin box fold superfamily

    RNA

    1. XR_881434.4 RNA Sequence

    2. XR_001784166.3 RNA Sequence

    3. XR_001784165.3 RNA Sequence

    4. XR_003954988.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018856.2: Suppressed sequence

      Description
      NM_018856.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJA7.1 GenPept UniProtKB/Swiss-Prot:Q9JJA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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