Arhgap8 Rho GTPase activating protein 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap8provided by MGI
Official Full Name: Rho GTPase activating protein 8provided by MGI
Primary source: MGI:MGI:1920417
See related: Ensembl:ENSMUSG00000078954 AllianceGenome:MGI:1920417
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3110043J09Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade. Is expressed in several structures, including ear; foregut; forelimb bud; heart; and lung. Orthologous to human ARHGAP8 (Rho GTPase activating protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 7.0), genital fat pad adult (RPKM 6.1) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E2; 15 39.99 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (84604214..84657058)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (84720034..84772857)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho GTPase-activating protein 8

Names: rho-type GTPase-activating protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164627.1 → NP_001158099.1 rho GTPase-activating protein 8

See identical proteins and their annotated locations for NP_001158099.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AK086816, AL513352, AL611987

Consensus CDS

CCDS27712.1

UniProtKB/Swiss-Prot

Q99JY7, Q9CXP4

UniProtKB/TrEMBL

Q8C2P4

Related

ENSMUSP00000006029.5, ENSMUST00000006029.11

Conserved Domains (2) summary

pfam13716
Location:32 → 165

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02570
Location:193 → 381

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
NM_001164628.1 → NP_001158100.1 rho GTPase-activating protein 8

See identical proteins and their annotated locations for NP_001158100.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AK086816, AL513352, AL611987

Consensus CDS

CCDS27712.1

UniProtKB/Swiss-Prot

Q99JY7, Q9CXP4

UniProtKB/TrEMBL

Q8C2P4

Related

ENSMUSP00000130977.2, ENSMUST00000168811.2

Conserved Domains (2) summary

pfam13716
Location:32 → 165

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02570
Location:193 → 381

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
NM_001205334.1 → NP_001192263.1 rho GTPase-activating protein 8

See identical proteins and their annotated locations for NP_001192263.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AL513352, AL611987

Consensus CDS

CCDS27712.1

UniProtKB/Swiss-Prot

Q99JY7, Q9CXP4

UniProtKB/TrEMBL

Q8C2P4

Conserved Domains (2) summary

pfam13716
Location:32 → 165

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02570
Location:193 → 381

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
NM_028455.4 → NP_082731.2 rho GTPase-activating protein 8

See identical proteins and their annotated locations for NP_082731.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AL513352, AL611987

Consensus CDS

CCDS27712.1

UniProtKB/Swiss-Prot

Q99JY7, Q9CXP4

UniProtKB/TrEMBL

Q8C2P4

Conserved Domains (2) summary

pfam13716
Location:32 → 165

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02570
Location:193 → 381

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

84604214..84657058

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521468.4 → XP_006521531.1 rho GTPase-activating protein 8 isoform X2

See identical proteins and their annotated locations for XP_006521531.1

UniProtKB/TrEMBL

Q8C2P4

Conserved Domains (2) summary

pfam13716
Location:87 → 220

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02570
Location:248 → 436

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_036159613.1 → XP_036015506.1 rho GTPase-activating protein 8 isoform X1

UniProtKB/TrEMBL

Q8C2P4

Conserved Domains (2) summary

cd00170
Location:67 → 168

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl02570
Location:204 → 392

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_006521470.3 → XP_006521533.1 rho GTPase-activating protein 8 isoform X4

See identical proteins and their annotated locations for XP_006521533.1

UniProtKB/Swiss-Prot

Q99JY7, Q9CXP4

UniProtKB/TrEMBL

Q8C2P4

Conserved Domains (2) summary

pfam13716
Location:32 → 165

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02570
Location:193 → 381

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_017316756.2 → XP_017172245.1 rho GTPase-activating protein 8 isoform X5

Conserved Domains (1) summary

pfam13716
Location:87 → 220

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006521469.4 → XP_006521532.1 rho GTPase-activating protein 8 isoform X2

See identical proteins and their annotated locations for XP_006521532.1

UniProtKB/TrEMBL

Q8C2P4

Conserved Domains (2) summary

pfam13716
Location:87 → 220

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02570
Location:248 → 436

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_006521471.4 → XP_006521534.1 rho GTPase-activating protein 8 isoform X4

See identical proteins and their annotated locations for XP_006521534.1

UniProtKB/Swiss-Prot

Q99JY7, Q9CXP4

UniProtKB/TrEMBL

Q8C2P4

Conserved Domains (2) summary

pfam13716
Location:32 → 165

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02570
Location:193 → 381

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_036159614.1 → XP_036015507.1 rho GTPase-activating protein 8 isoform X3

Conserved Domains (2) summary

cd00170
Location:5 → 70

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl02570
Location:106 → 294

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...