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    Sbno2 strawberry notch 2 [ Mus musculus (house mouse) ]

    Gene ID: 216161, updated on 14-May-2024

    Summary

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    Official Symbol
    Sbno2provided by MGI
    Official Full Name
    strawberry notch 2provided by MGI
    Primary source
    MGI:MGI:2448490
    See related
    Ensembl:ENSMUSG00000035673 AllianceGenome:MGI:2448490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sno; Stno; F730040C21
    Summary
    Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and macrophage activation involved in immune response. Acts upstream of or within several processes, including bone mineralization; bone trabecula morphogenesis; and osteoclast fusion. Predicted to be active in nucleus. Is expressed in submandibular gland primordium and vibrissa. Orthologous to human SBNO2 (strawberry notch homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 34.9), spleen adult (RPKM 33.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sbno2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79892826..79941942, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80056992..80106108, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6880 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide E Neighboring gene STARR-seq mESC enhancer starr_27262 Neighboring gene STARR-positive B cell enhancer ABC_E900 Neighboring gene glutathione peroxidase 4 Neighboring gene STARR-seq mESC enhancer starr_27263 Neighboring gene STARR-seq mESC enhancer starr_27266 Neighboring gene serine/threonine kinase 11 Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E11444 Neighboring gene STARR-positive B cell enhancer ABC_E1806 Neighboring gene ATP synthase F1 subunit delta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system. Syme TE, et al. J Neuroinflammation, 2022 May 27. PMID 35624480, Free PMC Article
    2. Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system. Grill M, et al. Glia, 2015 Oct. PMID 25903009, Free PMC Article
    3. A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal. Baba K, et al. Biochem Biophys Res Commun, 2006 Dec 1. PMID 17045962
    4. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. El Kasmi KC, et al. J Immunol, 2007 Dec 1. PMID 18025162
    5. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. Maruyama K, et al. J Exp Med, 2013 Sep 23. PMID 23980096, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SBNO2 provides negative feedback to the transcriptional response to IL-6
      Title: Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system.
    2. The findings of this study are consistent with SBNO2 functioning as an acute inflammatory response gene in astrocytes as well as other cells in the CNS.
      Title: Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.
    3. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
      Title: Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
    4. The SBNO2 is component of the pathways that contribute to the downstream anti-inflammatory effects of IL-10.
      Title: Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone trabecula morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-11 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to interleukin-6 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interleukin-6 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to leukemia inhibitory factor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macrophage activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macrophage activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macrophage activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multinuclear osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoclast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein strawberry notch homolog 2
    Names
    strawberry notch homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359635.1 → NP_001346564.1  protein strawberry notch homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK149806, BC032886, BC056369
      UniProtKB/TrEMBL
      A0A1W2P7W8
      Related
      ENSMUSP00000151854.2, ENSMUST00000218630.2
      Conserved Domains (3) summary
      pfam13871
      Location:726 → 1004
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1
      pfam17061
      Location:34 → 165
      PARM

    2. NM_001359636.1 → NP_001346565.1  protein strawberry notch homolog 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BC064113
      UniProtKB/TrEMBL
      A0A1W2P6Y8
      Related
      ENSMUST00000217876.2
      Conserved Domains (1) summary
      pfam13872
      Location:138 → 426
      AAA_34; P-loop containing NTP hydrolase pore-1

    3. NM_001359637.1 → NP_001346566.1  protein strawberry notch homolog 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159999, BC056369
      UniProtKB/TrEMBL
      A0A1W2P7W9
      Related
      ENSMUST00000217683.2

    4. NM_183426.2 → NP_906271.1  protein strawberry notch homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_906271.1

      Status: VALIDATED

      Source sequence(s)
      BC032886, BC056369
      Consensus CDS
      CCDS24008.1
      UniProtKB/Swiss-Prot
      Q3UE14, Q6P3A3, Q70X02, Q7TNB8
      UniProtKB/TrEMBL
      A0A1W2P7W8
      Related
      ENSMUSP00000041635.8, ENSMUST00000042771.8
      Conserved Domains (3) summary
      pfam13871
      Location:726 → 1004
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1
      pfam17061
      Location:34 → 165
      PARM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79892826..79941942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513494.1 → XP_006513557.1  protein strawberry notch homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006513557.1

      UniProtKB/Swiss-Prot
      Q3UE14, Q6P3A3, Q70X02, Q7TNB8
      UniProtKB/TrEMBL
      A0A1W2P7W8
      Conserved Domains (3) summary
      pfam13871
      Location:726 → 1004
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1
      pfam17061
      Location:34 → 165
      PARM

    2. XM_036155737.1 → XP_036011630.1  protein strawberry notch homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A1W2P7W8
      Conserved Domains (3) summary
      pfam13871
      Location:726 → 960
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1
      pfam17061
      Location:34 → 165
      PARM

    3. XM_036155736.1 → XP_036011629.1  protein strawberry notch homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A1W2P7W8
      Conserved Domains (3) summary
      pfam13871
      Location:726 → 960
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1
      pfam17061
      Location:34 → 165
      PARM

    4. XM_006513495.3 → XP_006513558.1  protein strawberry notch homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_006513558.1

      UniProtKB/TrEMBL
      A0A1W2P7W8
      Conserved Domains (3) summary
      pfam13871
      Location:726 → 1004
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1
      pfam17061
      Location:34 → 165
      PARM

    5. XM_006513492.1 → XP_006513555.1  protein strawberry notch homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006513555.1

      UniProtKB/Swiss-Prot
      Q3UE14, Q6P3A3, Q70X02, Q7TNB8
      UniProtKB/TrEMBL
      A0A1W2P7W8
      Related
      ENSMUSP00000151590.2, ENSMUST00000219260.2
      Conserved Domains (3) summary
      pfam13871
      Location:726 → 1004
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1
      pfam17061
      Location:34 → 165
      PARM

    6. XM_036155740.1 → XP_036011633.1  protein strawberry notch homolog 2 isoform X8

      Conserved Domains (2) summary
      pfam13871
      Location:332 → 610
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:2 → 106
      AAA_34; P-loop containing NTP hydrolase pore-1

    7. XM_036155739.1 → XP_036011632.1  protein strawberry notch homolog 2 isoform X8

      Conserved Domains (2) summary
      pfam13871
      Location:332 → 610
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:2 → 106
      AAA_34; P-loop containing NTP hydrolase pore-1

    8. XM_036155741.1 → XP_036011634.1  protein strawberry notch homolog 2 isoform X9

      Conserved Domains (2) summary
      pfam13871
      Location:332 → 610
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:2 → 106
      AAA_34; P-loop containing NTP hydrolase pore-1

    9. XM_036155738.1 → XP_036011631.1  protein strawberry notch homolog 2 isoform X8

      Conserved Domains (2) summary
      pfam13871
      Location:332 → 610
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:2 → 106
      AAA_34; P-loop containing NTP hydrolase pore-1

    10. XM_006513493.1 → XP_006513556.1  protein strawberry notch homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006513556.1

      UniProtKB/Swiss-Prot
      Q3UE14, Q6P3A3, Q70X02, Q7TNB8
      UniProtKB/TrEMBL
      A0A1W2P7W8
      Conserved Domains (3) summary
      pfam13871
      Location:726 → 1004
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1
      pfam17061
      Location:34 → 165
      PARM

    11. XM_017313890.3 → XP_017169379.1  protein strawberry notch homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A1W2P7W8
      Conserved Domains (2) summary
      pfam13871
      Location:710 → 988
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:196 → 484
      AAA_34; P-loop containing NTP hydrolase pore-1

    12. XM_017313891.3 → XP_017169380.1  protein strawberry notch homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A1W2P7W8
      Conserved Domains (2) summary
      pfam13871
      Location:652 → 930
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:138 → 426
      AAA_34; P-loop containing NTP hydrolase pore-1

    13. XM_006513497.5 → XP_006513560.1  protein strawberry notch homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A1W2P7W8
      Conserved Domains (2) summary
      pfam13871
      Location:652 → 930
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:138 → 426
      AAA_34; P-loop containing NTP hydrolase pore-1

    RNA

    1. XR_003948671.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNB8.1 GenPept UniProtKB/Swiss-Prot:Q7TNB8

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