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    Fam83d family with sequence similarity 83, member D [ Mus musculus (house mouse) ]

    Gene ID: 71878, updated on 4-May-2024

    Summary

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    Official Symbol
    Fam83dprovided by MGI
    Official Full Name
    family with sequence similarity 83, member Dprovided by MGI
    Primary source
    MGI:MGI:1919128
    See related
    Ensembl:ENSMUSG00000027654 AllianceGenome:MGI:1919128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310007D09Rik
    Summary
    Predicted to enable kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm; intercellular bridge; and mitotic spindle. Predicted to be active in cytosol and mitotic spindle pole. Is expressed in diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory epithelium; and telencephalon ventricular layer. Orthologous to human FAM83D (family with sequence similarity 83 member D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in stomach adult (RPKM 15.0), colon adult (RPKM 14.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam83d in Genome Data Viewer
    Location:
    2 H1; 2 78.73 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158610011..158628557)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158768099..158786637)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10158 Neighboring gene ARP5 actin-related protein 5 Neighboring gene microRNA 3474 Neighboring gene STARR-positive B cell enhancer ABC_E7879 Neighboring gene STARR-positive B cell enhancer mm9_chr2:158499319-158499620 Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene STARR-positive B cell enhancer ABC_E2650 Neighboring gene STARR-positive B cell enhancer ABC_E7880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:158548828-158549026 Neighboring gene STARR-positive B cell enhancer ABC_E2056 Neighboring gene STARR-positive B cell enhancer ABC_E7881 Neighboring gene STARR-positive B cell enhancer ABC_E416 Neighboring gene STARR-seq mESC enhancer starr_06234 Neighboring gene DEAH-box helicase 35 Neighboring gene STARR-seq mESC enhancer starr_06235 Neighboring gene STARR-positive B cell enhancer ABC_E6010 Neighboring gene STARR-seq mESC enhancer starr_06237 Neighboring gene predicted gene, 38630 Neighboring gene STARR-seq mESC enhancer starr_06238

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TAF4b transcription networks regulating early oocyte differentiation. Gura MA, et al. Development, 2022 Feb 1. PMID 35043944, Free PMC Article
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC92947

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle G1/S phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM83D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418738.1 → NP_001405667.1  protein FAM83D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663077, AL669910

    2. NM_027975.3 → NP_082251.2  protein FAM83D isoform 1

      See identical proteins and their annotated locations for NP_082251.2

      Status: VALIDATED

      Source sequence(s)
      AL663077, AL669910
      Consensus CDS
      CCDS50788.1
      UniProtKB/Swiss-Prot
      A2AC91, Q3TXE0, Q6P396, Q8BYC0, Q9D7I8
      Related
      ENSMUSP00000029183.3, ENSMUST00000029183.3
      Conserved Domains (2) summary
      pfam13091
      Location:149 → 284
      PLDc_2; PLD-like domain
      cl15239
      Location:21 → 291
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    RNA

    1. NR_184811.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL663077, AL669910

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      158610011..158628557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162579.1 → XP_036018472.1  protein FAM83D isoform X1

      Conserved Domains (1) summary
      cl15239
      Location:13 → 92
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7I8.1 GenPept UniProtKB/Swiss-Prot:Q9D7I8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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